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EC number: 294-785-9 | CAS number: 91770-03-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Stability in organic solvents and identity of relevant degradation products
Administrative data
Link to relevant study record(s)
- Endpoint:
- stability in organic solvents and identity of relevant degradation products
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1998-03-05 to 1998-12-15
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- restriction due to limited details provided in the study report about analytical conditions used for the chromatographic analysis.
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The stability of the test material as a solution in arachis oil ( the vehicle used in 90-day repeated dose oral toxicity study) was determined by HPLC. Chromatograms of the test substance in the vehicle were compared after 14 days of storage to a chromatogram of the test material in the vehicle immediately after preparation. Chromatograms were compared both qualitatively (by retention times of eluted peaks) and quantitatively on the basis of peak areas. Results of the analysis are used as the basis for determining if the test material is stable in the vehicle for the duration of study.
- GLP compliance:
- yes
- Test substance stable:
- yes
- Transformation products:
- no
- Conclusions:
- The test substance is stable as a solution in arachis oil for 14 days. Arachis oil is suitable for use as a vehicle in the 90-day repeated dose oral toxicity study.
- Executive summary:
The stability of the test substance in arachis oil, used as the vehicle in a 90-day repeated dose oral toxicity study, was determined by comparing the chromatograms of the test substance stored in this vehicle at concentrations of 25, 250 and 500 mg/mL on day 0 and on day 14. The post-storage mean concentrations were 92-96% of the initial concentration after 14 days.
Reference
Table 1: Stability of test material formulations
Nominal concentration (mg/mL) |
Concentration found initially (mg/mL) |
Concentration found after storage for 14 days |
|
mg/mL |
Expressed as % of initial |
||
25 |
22.1 |
21.1 |
96 |
250 |
235 |
219 |
93 |
500 |
508 |
468 |
92 |
Description of key information
The test substance was determined to be stable in arachis oil for 14 days (procedures associated with OECD 408).
Additional information
The stability of the test substance in arachis oil, used as the vehicle in a 90-day repeated dose oral toxicity study, was determined by comparing the chromatograms of the test substance stored in this vehicle at concentrations of 25, 250 and 500 mg/mL on day 0 and on day 14. The post-storage mean concentrations were 92-96% of the initial concentration after 14 days.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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