Registration Dossier
Registration Dossier
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EC number: 217-752-2 | CAS number: 1948-33-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Justification for type of information:
- Data is from study report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute oral toxicity of test chemical in rats
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- 2-tert-butylhydroquinone
- EC Number:
- 217-752-2
- EC Name:
- 2-tert-butylhydroquinone
- Cas Number:
- 1948-33-0
- Molecular formula:
- C10-H14-O2
- IUPAC Name:
- 2-tert-butylbenzene-1,4-diol
- Details on test material:
- - Name of test material: 2-tert-butylhydroquinone
- Molecular formula: C10H14O2
- Molecular weight: 166.22
- Substance type: Organic
- Physical state: Solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Not available
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- other: Jaguar
- Details on oral exposure:
- No other details available
- Doses:
- 50-3200 mg/kg
- No. of animals per sex per dose:
- 4
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levelsopen allclose all
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 951 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other:
- Remarks:
- 50% mortality observed
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 131 mL/kg bw
- Based on:
- test mat.
- Remarks on result:
- other:
- Remarks:
- 50% mortality observed
- Mortality:
- 50% mortality observed at 951 mg/kg bw and 1131 mg/kg bw
- Clinical signs:
- other: Slight weakness
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Conclusions:
- The acute oral median lethal dose (LD50) of test chemical in male and female rat was found to be 951 and 1131 mg/kg of body weight respectively.
- Executive summary:
Acute oral toxicity study of test chemical was conducted on male and female rats at the dose concentration of 951 and 1131 mg/kg bw. The test chemical was administered via oral unspesified route. All animals were maintained under close observation for recording toxic signs and time of death for 14 days. Clinical signs of slight weakness were observed. Therefore, LD50 value was considered to be 951 and 1131 mg/kg bw when rats were treated with test chemical via oral route.
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