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EC number: 217-316-1
CAS number: 1809-19-4
Table: Eye irritation results.
The eye irritation potential of the
substance was evaluated in an experimental study performed according to
the criteria specified in paragraph 191.12 of the final Order,
Enforcement regulations, federeal regulation, federal registror vol. 29,
N 192, P.13009, 17 september 1964, a method similar to the OECD Guideline
405. The test item was applied directly into the the eye of three albino
rabbits and the site was monitored for corneal opacity, iritis,
conjunctival redness and chemosis according to Draize scores,
immediately after application and then at 1, 2, 3 and 7 days after
Corneal opacity scores were 1.0 in all
animals at all time points, with the exception of the 7 day reading,
which was 0.0 in two out of the three animals. Iritis scores were 1.0 in
all animals both immediately after application and after 1 day; 2 days
after application, the iritis scores were 0.0 for two animals and 1.0
for one animal, after which time the iritis scores were 0.0 for all
animals until end of study period. Conjunctival redness scores were 2.0
in all animals immediately after application; 1.0 in all animals after
both 1 and 2 days; 0.0 (1 animal) and 1.0 (2 animals) after 3 days, and
0.0 among all animals after 7 days. Conjunctival chemosis scores were
2.0 among all animals immediately after application; 1.0 among all
animals after 1 day; and 1.0 (2 animals) and 0.0 (1 animal) after 2
days; all animals had scores of 0.0 after 3 and 7 days.
The mean (24/48/72 hour) scores for the
four parameters examined can be interpreted for each animal as follows:
corneal opacity = 1.0 (all animals); iritis = 0.33 and 0.67 (2 and 1
animals, respectively); conjunctival redness = 0.67 and 1.0 (1 and 2
animals, respectively); chemosis = 0.33 and 0.67 (1 and 2 animals,
It is apparent that the test item is
irritating to the rabbit eye, however, it should be noted that all
parameters were reversible within a 7-day window with the exception of a
corneal opacity score of 1.0 in one rabbit only after 7 days.
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