Registration Dossier
Registration Dossier
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EC number: 217-316-1 | CAS number: 1809-19-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 11 July to 6 August, 1973
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- fixed dose procedure
- Limit test:
- no
Test material
- Reference substance name:
- Dibutyl phosphonate
- EC Number:
- 217-316-1
- EC Name:
- Dibutyl phosphonate
- Cas Number:
- 1809-19-4
- Molecular formula:
- C8H19O3P
- IUPAC Name:
- dibutyl phosphonate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Diet: ad libitum
- Water: ad libitum
- Acclimation period: 7 days
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Doses:
- 1000, 3000 mg/kg bw
- No. of animals per sex per dose:
- 10 animals per dose
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 3 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- One rat during the first day of observation period after administration of the highest dose.
- Clinical signs:
- other:
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified according to CLP Regulation (EC no. 1272/2008)
- Conclusions:
- LD50 (oral, rat) > 3000 mg/kg bw
- Executive summary:
The acute oral toxicity of the test item was evaluated in an experimental study similar to the OECD Guideline 420, according to the fixed dose procedure. The test item was administered to groups of 10 male/female Wistar rats by oral gavage, at doses of 1000 or 3000 mg/kg bw. One rat from the low-dose group died on the first day of the observation period; no further mortality occurred in either group. The acute oral LD50 is, therefore, considered to be greater than 3000 mg/kg bw.
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