Registration Dossier

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Additional information

For the aquatic toxicity of sodium methylparaben (CAS No. 5026-62-10) no data are available. Therefore, the assessment of the acute and long-term aquatic toxicity of sodium methylparaben is based on aquatic toxicity data of the corresponding acid methylparaben (CAS No. 99-76-3).

This read across approach is in accordance with Regulation (EC) No 1907/2006, Annex XI, 1.5. Grouping of substance and read across approach as is explained within the analogue justification in section 13. Except for different cations (hydrogen vs. sodium) the anions of both the source and target substance have identical chemical structures. Since dissociation of the sodium salt under environmental conditions (pH 4 - 9) yields the same ionic species as the acidic form of the substance, this read across can be considered as justified.

For the analogue read across substance methylparaben, acute data for different trophic levels (fish, invertebrates and algae) are available. Acute toxicity testing with fish resulted in an EC50 (96 h) of 59.5 mg/L. Daphnia magna turned out to be the most sensitive species with an EC50 (48 h) of 11.2 mg/L. The ErC50 (72 h) for algae is reported to be 91 mg/L.

In addition, long-term toxicity data from tests with methylparaben are available for invertebrates and algae. Again Daphnia magna was more sensitive to methylparaben with a NOEC (21 d) of 0.2 mg/L while the NOErC (72 h) for algae is reported to be 20 mg/L.

Data on the inhibition of microbial respiration are not available because testing of this endpoint is not necessary as methylparaben is readily biodegradable and the applied test concentrations in the ready biodegradation test of 20 mg/L are higher than the range of concentrations that can be expected in the influent of a sewage treatment plant.