Registration Dossier
Registration Dossier
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EC number: 231-674-6 | CAS number: 7681-65-4
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
- According to Directive 67/548/EEC: Irritant (Xi). R38, Irritating to skin.
- According to CLP/GHS: Category 2 Irritant. H315, Causes skin irritation.
- According to Directive 67/548/EEC: Irritant (Xi). R41, risk of serious damage to eyes.
- According to CLP/GHS: Eye Damage 1, H318: Causes serious eye damage.
Skin irritation/corrosivity:
A GLP-compliant in-vitro skin corrosivity test was conducted in accordance with the requirements of OECD Guideline 431 (Warren, 2012b). Data were presented in the form of percentage viability (MTT reduction in the test item treated tissues relative to negative control tissues). The relative mean viability of the test item treated tissues was as follows: 240 minutes exposure, 67.7%; 60 minutes exposure, 84.7%; 3 minutes exposure, 94.2%. Copper iodide is unclassified with regard to skin corrosivity.
A GLP-compliant in-vitro skin irritation test was conducted in accordance with the requirements of OECD Guideline 439 and EU Method B.46 (Warren, 2012a). Data were presented in the form of percentage viability. The relative mean viability of the test item treated tissues was 16.5% after a 15 minute exposure. On this basis it is concluded that copper iodide is irritating in contact with skin and that the following classification applies:
Eye irritation/corrosivity:
A GLP-compliant eye irritation test was carried out in two rabbits in accordance with OECD Guideline 405 and EU Method B5 (Bradshaw, 2012c). The persistence of reactions in the treated eye at the 21 -Day observation was indicative of irreversible ocular damage. The test item was considered to be corrosive to the rabbit eye and was classified as follows:
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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