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EC number: 229-222-8 | CAS number: 6440-58-0
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Reliable (Klimisch 1 or 2) short-term toxicity studies with invertebrates have been conducted for DMDMH and its hydrolysis products and are included in this dossier. As a conservative approach, the most sensitive result across these substances has been taken as the endpoint for DMDMH. The key study, Ciliutti (2003), provides a 48-hr EC50 of 29.1 mg/L for Daphnia magna. Consequently this value will be taken as the short-term toxicity in aquatic invertebrate endpoint for DMDMH.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 29.1 mg/L
Additional information
Reliable (Klimisch 1 or 2) short-term toxicity studies with invertebrates have been conducted for DMDMH or the hydrolysis product of DMDMH, DMH and are included in this dossier. Studies conducted with the hydrolysis product, DMH, are considered relevant for environmental fate and ecotoxicology and are considered in this dossier.
Ciliutti (2003) conducted a reliable (Klimisch 1) GLP compliant study following OECD 202 methods. Daphnia magna, <24 hrs old, were exposed to measured concentrations (61.3, 30.3, 12.7, 6.61 and 2.42 mg/l) of DMDMH in a semi-static system for 48 hours. The 48hr EC50, based on immobilization, was 29.1 mg/L.
Horne et al., (1980) conducted a reliable (Klimisch 2) study following methods for registration of pesticides in the U.S. Daphnia magna were exposed to nominal concentrations (3000, 5000, 7000, 10000 and 15000 mg/l) of the hydrolysis product of DMDMH, DMH in a static system for 48 hours. The 48hr EC50, based on immobilization, was 6200 mg/L.
Industrial Biotest Laboratories (1982) conducted a reliable (Klimisch 2) study without following a specified guideline. Daphnia magna, about 24 hrs old, were exposed to nominal concentrations (10, 18, 32, 56 and 100 mg/l) of DMDMH in a static system for 96 hours. The 96-hr LC50, based on immobilization, was 37 mg/L.
Reliable (Klimisch 1 or 2) short-term toxicity studies with invertebrates have been conducted for DMDMH and its hydrolysis products and are included in this dossier. As a conservative approach, the most sensitive result across these substances has been taken as the endpoint for DMDMH. The key study, Ciliutti (2003), provides a 48-hr EC50 of 29.1 mg/L for Daphnia magna. Consequently this value will be taken as the short-term toxicity in aquatic invertebrate endpoint for DMDMH.
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