Registration Dossier
Registration Dossier
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EC number: 229-222-8 | CAS number: 6440-58-0
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
No reliable (Klimisch 1 or 2) long-term toxicity studies with fish have been conducted for DMDMH, although a reliable (Klimisch 1) long-term toxicity study with fish using DMH is included in this dossier. The study (Holmes & Swigert 1993) provides an estimated NOEC of 14 mg/L based on growth. Consequently this value will be taken as the long-term toxicity in fish endpoint for DMDMH.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 14 mg/L
Additional information
No reliable (Klimisch 1 or 2) long-term toxicity studies with fish have been conducted for DMDMH. However, a reliable study has been conducted with the hydrolysis product of DMDMH, DMH, and is included in this dossier.DMDMH readily undergoes hydrolysis to DMH and therefore data is provided for both substances when available. In the case of long-term testing, the data on DMH are considered more relevant for environmental fate and ecotoxicology and are considered in this dossier.
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The long-term toxicity DMH to fish was investigated by Holmes & Swigert (1993) (Klimisch 1) in a GLP compliant test. Fathead minnow (Pimephales promelas) fertilized embryos were exposed to measured concentrations (6.8, 14, 29, 55, and 116 mg/L) of the test substance following methods similar to OECD 210/212. The 33-day flow-through test was initiated with eyed-eggs and hatchability and time to hatch and growth and survival were measured. There were no effects upon the hatching, survival, length or wet weight of fish to any exposure concentration of DMH tested. However, effects were seen in the dry weight of fish at the three highest concentrations. Therefore, the NOEC based on growth, using DMH is 14 mg/L and this is considered to be representative of the long-term toxicity potential of DMDMH. Based on the half-life of DMDMH of <1 day (pH 7) it is considered scientifically unjustified to perform a long-term toxicity study using DMDMH.
No reliable (Klimisch 1 or 2) long-term toxicity studies with fish have been conducted for DMDMH, although a reliable (Klimisch 1) long-term toxicity study with fish using DMH is included in this dossier. The study (Holmes & Swigert 1993) provides an estimated NOEC of 14 mg/L based on growth. Consequently this value will be taken as the long-term toxicity in fish endpoint for DMDMH.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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