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EC number: 800-940-9 | CAS number: 35836-72-7
Table 7.4.1/1: Results of skin sensitization
Treatment and concentrations
No. of nodes per group
dpm per group
dpm per node
Stimulation index (SI)
Increase in ear thickness (% between Day 1 and Day 6)
α-hexylcinnamaldehyde 25 %
dpm = disintegrations per minute
I = non-irritant (increase in ear thickness < 10 %)
EC3 value = theoretical concentration resulting in a SI value of
stimulation index = dpm of treated group / dpm of control group
In a local lymph node assay performed according to OECD Guideline No 429 and in compliance with GLP, groups of CBA/J mice (4 females/dose)
No clinical signs and no mortality were observed during the main test. No local reactions and no notable increase in ear thickness were observed at any of the tested concentrations. Stimulation Index for 5, 10, 25, 50 and 100 % was 0.73, 1.44, 7.14, 3.61 and 3.63, respectively. The calculated effective concentration inducing a SI of 3 (EC3) was 14.11 %. Positive control (α-hexylcinnamaldehyde) exhibited evidence of sensitisation (SI = 10.08).
A significant lymphoproliferation (SI > 3) was noted at concentrations ≥ 25%. In the absence of local irritation, the significant lymphoproliferative responses observed were attributed to delayed contact hypersensitivity.
Therefore, nopyl acetate is classified as sensitising "R43: may cause sensitisation by skin contact" according to Directive 67/548/EEC and skin sensitiser Category 1B according to Regulation (EC) No 1272/2008 (CLP).
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