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EC number: 800-940-9
CAS number: 35836-72-7
In an acute dermal toxicity study (limit
test), a group of 10 New Zealand White rabbits were administered a
single dermal dose of nopyl acetate at 2000 mg/kg bw on clipped abraded
abdominal skin using an occlusive patch for 24 h. Animals were then
observed for mortality, clinical signs, bodyweights and dermal reactions
for 7 days and were all macroscopically necropsied after sacrifice.
No deaths occurred throughout the study.
Normal body weight gain was observed in all animals. At necropsy,
macroscopic examination of main organs showed no abnormalities. Adverse
dermal reactions noted were slight to moderate erythema and edema, which
completely recovered to normal within four days. The acute dermal LD50
was therefore greater than 2000 mg/kg bw under test conditions.
The acute dermal LD50 of nopyl
acetate is greater than 2000 mg/kg bw in rabbits. Therefore it is not
classified for acute dermal toxicity according to Directive 67/548/EEC
and according to CLP Regulation (EC) No 1272/2008.
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