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Diss Factsheets
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EC number: 213-926-7 | CAS number: 1067-25-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1994-09-26 to 1994-09-30
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: 1000 mg/L
- Sampling method: Samples of test medium were taken at the start of the test and then after 24 hours in the old medium prior to renewal. Samples of freshly prepared medium were taken again when the test medium was renewed after 24, 48 and 72 hours. - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: A stock solution of 1 g test substance in 1 L drinking water was prepared by mixing for 18 h followed by filtration. No further details were provided on the filtration step.
- Other: The test medium was freshly prepared from the stock solution every day. - Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: Zebrafish
- Source: West aquarium, Bad Lauterberg, Germany
- Length at study initiation: 3.0 cm +/-0.5 cm
- Feeding during test: None
METHOD OF BREEDING
- Maintenance of the brood fish: The fish were held in 200 L stoneware or 300 L glassware tanks filled with dechlorinated drinking water at 20 °C ± 2 °C in a flow-through system.
- Type and amount of food: TetraMin® at 1% of body weight
- Feeding frequency: Daily
- Mortality: Mortality was ≤ 5% 7 d before test start.
ACCLIMATION
- Acclimation period: At least 14 days quarantine
- Acclimation conditions (same as test or not): Yes
- Treatment: The fish are treated with malachite green 3 times per week during the 2-week quarantine period.
- Health during acclimation: The fish exhibit normal behaviour and are free from visible signs of disease at the start of the test. - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Hardness:
- 11.3 ºdH
- Test temperature:
- 20 - 21ºC
- pH:
- 7.7 - 8.5
- Dissolved oxygen:
- 60 - 102% ASV
- Nominal and measured concentrations:
- Nominal concentration: Control, 1000 mg/l
Measured concentration: Control, 746 mg/L (mean measured concentration of the freshly prepared test media)
Initial measured concentration in fresh medium at the start of the test: 823.3 mg/l
Measured concentration in old medium prior to renewal and after 24 h exposure: 687.5 mg/l
Measured concentration in fresh media prepared for renewal at 24, 48 and 72 h: 654.6, 731.6 and 774.1 mg/l - Details on test conditions:
- TEST SYSTEM
- Test vessel: 20 L aquarium
- Type: Open
- Aeration: Yes, continuous
- Renewal rate of test solution: Daily
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Potable water from Gelsenwasser AG
- Volume: 10 L
OTHER TEST CONDITIONS
- Adjustment of pH: No
- Photoperiod: 16 hours light, 8 hours dark
EFFECT PARAMETERS MEASURED: Daily mortalities
TEST CONCENTRATIONS
- Spacing factor for test concentrations: Limit test - Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 746 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Remarks:
- but exposure is to hydrolysis products
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 746 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Remarks:
- but exposure is to hydrolysis products
- Basis for effect:
- mortality (fish)
- Details on results:
- - Mortality of control: 0
- Reported statistics and error estimates:
- There were no toxic effects observed in the test and statistical analysis of the results was not undertaken.
- Sublethal observations / clinical signs:
ANALYTICAL RESULTS
The stability check resulted in deviations in concentration of < 20%. Therefore, it is concluded that neither the parent substance nor the hydrolysis products are biodegraded or volatilized and the results were based on the arithmetic mean measured concentration.
- Validity criteria fulfilled:
- yes
- Conclusions:
- A 96-h LC50 value of >746 mg/L and NOEC of ≥746 mg/L have been determined for the effects of the test substance on mortality of Brachydanio rerio based on mean measured concentrations. It is likely that the test organisms were exposed to the hydrolysis products of the substance.
Reference
Description of key information
LC50 (96 h) > 746 mg/L (arithmetic mean measured, EU method C1, B. rerio, RL 1), equivalent to 554 mg/L when expressed in terms of the silanol hydrolysis product
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- LC50
- Remarks:
- 96 h
- Effect concentration:
- > 554 mg/L
Additional information
A 96 hr LC50 of >746 mg/l (EU Method C.1 (Acute Toxicity for Fish) was determined for the effects of trimethoxypropylsilane on mortality of Brachydanio rerio based on mean measured concentrations.
However as the substance rapidly hydrolyses (half-life approximately 2.6 hours) to propysilanetriol, it is therefore likely that the test organisms were primarily exposed to hydrolysis product retained in the test media.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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