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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
dermal absorption
Type of information:
(Q)SAR
Adequacy of study:
supporting study
Study period:
2011
Reliability:
2 (reliable with restrictions)
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
other: QSAR calculation
Title:
Unnamed
Year:
2011
Report date:
2011

Materials and methods

Principles of method if other than guideline:
The Dermal Permeability Coefficient Program (DERMWIN) v2.00 was used to calculate the dermal permeability coefficient (Kp), the dermally absorbed dose per event (DAevent) and Dermal Absorbed Dose (DAD) of organic compounds via water contact.
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
melam
IUPAC Name:
melam
Constituent 2
Reference substance name:
n(c(nc(n1)Nc(nc(nc2N)N)n2)N)c1N
IUPAC Name:
n(c(nc(n1)Nc(nc(nc2N)N)n2)N)c1N
Radiolabelling:
no

Results and discussion

Applicant's summary and conclusion

Conclusions:
The dermal permeability coefficient (Kp) is predicted to 1.62e-005 cm/h.

Dermally Absorbed Dose (70 kg Adult) - Water Contact:
Result: DAD = 1.32e-004 mg/kg-day
Executive summary:

The Dermal Permeability Coefficient Program (DERMWIN) v2.00 estimates the dermal permeability coefficient (Kp), the dermally absorbed dose per event (DAevent) and Dermal Absorbed Dose (DAD) of organic compounds via water contact.

The dermal permeability coefficient (Kp) was predicted to 1.62e-005 cm/h.

Dermally Absorbed Dose (DA) per Event for Organic Compounds - Water Contact:

DA(event) = 1.25e-006 mg/cm2.

Dermally Absorbed Dose (DAD) (70 kg Adult) - Water Contact:

DAD = 1.32e-004 mg/kg-day