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EC number: 222-695-1
CAS number: 3576-88-3
The toxicokinetic behaviour of melam was estimated from available
data for the purpose of registration of the substance.
Absorption, distribution: No systemic effects were observed in
the acute oral toxicity studies even at high doses. No toxic effects
were detected in the repeated dose toxicity tests, too. Only unspecific,
possibly systemic effects (reduced body weight gain of the dams) were
detected in the teratogenicity studies at high doses of 1000 mg/kg bw.
Therefore it is concluded that an absorption after peroral
administration of the submitted substance might have occurred, at least
at high doses. No information on the distribution was obtained, as only
unspecific effects were noted.
The logPow is very low and does not favour an oral or an inhalation
absorption of the substance. Also the molecular mass of 235 does not
point to a good absorption.
Metabolism: No relevant differences occurred in the
mutagenicity studies with and without the addition of a metabolising
system. Therefore no indication of the importance of the metabolism of
the test substance was obtained from these studies.
Bioaccumulation: A potential for bioaccumulation is
unlikely, based on the low partition coefficient. No statement on the
bioaccumulation can be derived from the comparison of the effective
doses in the acute and the repeated dose oral toxicity study.
Excretion: No relevant data are available, which provide
evidence on the route of excretion.
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