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Diss Factsheets
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EC number: 200-880-8 | CAS number: 75-57-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: No guideline or GLP followed and the information given is very limited..
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 968
- Report date:
- 1968
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
- Type of method:
- in vivo
Test material
- Reference substance name:
- Tetramethylammonium chloride
- EC Number:
- 200-880-8
- EC Name:
- Tetramethylammonium chloride
- Cas Number:
- 75-57-0
- Molecular formula:
- C4H12N.Cl
- IUPAC Name:
- N,N,N-trimethylmethanaminium chloride
- Details on test material:
- - Name of test material (as cited in study report): tetramethylammonium chloride
- Source: Matheson, Coleman & Bell, Cincinnati, Ohio, USA
Constituent 1
Test animals
- Species:
- other: chicken
- Strain:
- other: White Leghorn
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Kimber Farms Inc., Niles, California, USA
- Age at study initiation: egg stage
ENVIRONMENTAL CONDITIONS
- Eggs were incubated in a Jamesway model 252B automatic egg incubator (James Manufacturing Co., Fort Atkinson, Wisconsin, USA)
- Temperature (°C):37.5
- Humidity (%): 73
Administration / exposure
- Route of administration:
- other: injection into yolk
- Vehicle:
- water
- Details on exposure:
- Volume = 0.1 ml
- Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- Embryos were collected from eggs on day 6
- Frequency of treatment:
- Single injection, on day 2 (2 eggs) or 4 (2 eggs)
- Duration of test:
- 6 days
Doses / concentrations
- Remarks:
- Doses / Concentrations:
10 mg/egg
Basis:
nominal conc.
- No. of animals per sex per dose:
- 4
- Control animals:
- other: unexposed eggs... (see attached file)
- Details on study design:
- This study was aimed at comparing the teratogenicity of insecticides with known neuro-toxicity with compounds that are known to be both neurotoxic and teratogenic, such as tetramethylammonium chloride.
The teratogenic effects of the compounds were investigated, furthermore the distribution of injected acetyl-1-14C-choline and its hydrolysis products.
Results and discussion
Effect levels
- Dose descriptor:
- dose level:
- Effect level:
- 10 other: mg/egg
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: Severe manifestation of teratogenic signs.
Observed effects
No differences were observed between the eggs exposed on day 2 or day 4.
Applicant's summary and conclusion
- Conclusions:
- Fertile eggs were injected with 10 mg/egg of the test substance. After 2 or 4 days, the embryo's were shown to have greatly reduced body length.
Based on these data, it can be concluded that at the dose level of 10 mg/egg tetramethylammonium chloride is teratogenic to chicken embryos. - Executive summary:
Fertile eggs were injected with 10 mg/egg of the test substance. Upon recovery of the embryo's at 2 or 4 days after injection of the test substance, the embryo's showed to have greatly reduced body length. No significant differences between the TMAC and untreated eggs were observed in distribution of acetyl-14C-choline, that was injected one day before embryo's were collected. No differences were observed between the eggs exposed on day 2 or day 4.
Based on these data, it can be concluded that at the dose level of 10 mg/egg tetramethylammonium chloride is teratogenic to chicken embryo's.
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