Registration Dossier
Registration Dossier
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EC number: 214-711-0 | CAS number: 1189-08-8
Endpoint summary
Administrative data
Description of key information
The ready biodegradation of 1,3 -BDDMA was assed by read across with structurally very similar substance 1,4 -BDDMA on structural analog approach.
The ready biodegradation ofthe structural analogue1,4 -BDDMA was investigated in a study conducted according to OECD Guideline 310 (Headspace test) , adopted 23 March 2006, over a period of 28 days and using predominantly domestic non-adapted activated sludge as inoculum. The biodegradation rate was determined by measurement of CO2 evolution. The 10% level (beginning of biodegradation) was reached after 2 days. The pass level of 60% was reached after 9 days and the biodegradation came to 84 % after 28 days. The 95% confidence interval on day 28 was 76 - 92% .
I a read across approach 1,3 -BDDMA is considered to be readily biodegradable, fulfilling the 10 -d window.
Additional information
The ready biodegradation of the structural analogue 1,4 -BDDMA was investigated in a study conducted according to OECD Guideline 310 (Headspace test) , adopted 23 March 2006, over a period of 28 days and using predominantly domestic non-adapted activated sludge as
inoculum. The biodegradation rate was determined by measurement of CO2 evolution. Inoculum blank, toxicity control and procedural/functional control with the reference substance sodium benzoate were performed.The functional control reached the pass level pass level of 60% after 3 days.
The 10% level (beginning of biodegradation) was reached after 2 days. The pass level of 60% was reached after 9 days and the biodegradation came to 84 % after 28 days. The 95% confidence interval on day 28 was 76 - 92%
The biodegradation of the toxicity control reached 83% within 14 days and 89% after 28 days. The biodegradation of the reference item was not inhibited by the test itemin the toxicity control.The 95% confidence interval on day 28was 86 - 93%
1,4-BDDMA was readily biodegradable fulfilling the 10-d window criterion.
In a supporting study 1,3-BDDMA has been tested for biodegradation:
The ready biodegradation of 1,3-BDDMA was investigated in a study conducted according to OECD Guideline 301 B (CO2 evolution test), adopted 17th July 1992, and EU Method C.4-C, 31 July 1992, over a period of 28 days and using domestic sewage as inoculum. The biodegradation rate was determined by measurement of CO2 evolution. Inoculum blank and procedural/functional control with the reference substance sodium acetate were performed.
The functional control reached the pass level >60% after 14 d (68.5%).
The 10-day window started on day 6. Biodegradation achieved 57% at the end of the 10 day window (day 16) and 74% at the end of the test period.
A degradation of 60% has to be reached in a 10-day window within 28 days in order to classify the test substance as readily biodegradable. Based on this criterion, 1,3-BDDMA is not readily biodegradable. But as the pass level is almost fulfilled (degradation slightly below 60%), the test substance can be considered as inherently biodegradable.
Considering close structural similarity to 1,4 -BDDMA, 1,3 -BDDMA is judged to be readily biodegradable.
According to Annex IX 9.2.1.2. Column 2, a study on biodegradation in water and sediment does not need to be conducted as the substance is readily biodegradable (experimental result please see chapter 5.2.1).
According to Annex IX 9.2.1.3. Column 2, a study on biodegradation in soil does not need to be conducted as the substance is readily biodegradable (experimental result please see chapter 5.2.1.).
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