Registration Dossier
Registration Dossier
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EC number: 273-489-3 | CAS number: 68987-29-1
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
No skin sensitization was observed in both studies, therefore 1-Octadecanol, phosphate, potassium salt is considered to be devoid of skin sensitization potential.
Justification for read-across:
The read-across approach is appropriate due to similar composition of source substance and registered substance. From the available data is can be concluded that the skin sensitization potential of substances with different alkyl moieties (C12 and C16) is comparable.
Data from source substance are conducted on alkyl phosphoric esters, whereas the substance to be registered is neutralized with potassium hydroxide. The irritation potential of the substances is considered to be different; however for skin sensitization there are no reasons to assume a different profile for this endpoint.
Migrated from Short description of key information:
1-Octadecanol, phosphate, potassium salt is not a dermal sensitizer.
Justification for selection of skin sensitisation endpoint:
Reliable data from two sensitization studies, conducted according to the method of Magnusson and Kligman, with the read-across substances Monolauryl phosphate and Hexadecyl dihydrogen phosphate are available.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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