(±)-2-(6-methoxy-2-naphthyl)propionic acid

Guidance on Safe Use

First-aid measures

See below

Fire-fighting measures

See below

Accidental release measures

See below

Handling and storage

See below

Transport information

Shipping

SpecialProvisions

Shipping

Remarks

Marine transport (UN RTDG/IMDG)

Shipping

Remarks

Shipping

Remarks

SpecialProvisions

Exposure controls / personal protection

HAZARDS

   Storage:

Keep in a cool, dry, dark location in a tightly sealed container or cylinder.  Keep away from incompatible materials, ignition sources and untrained individuals.  Secure and label area. Protect containers/cylinders from physical damage.

   Handling:

All chemicals should be considered hazardous.  Avoid direct physical contact.  Use appropriate, approved safety equipment.  Untrained individuals should not handle this chemical or its container.  Handling should occur in a chemical fume hood.

   Protection:

Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses.  Wear chemical resistant gloves.  To prevent repeated or prolonged skin contact, wear impervious clothing and boots.

   Respirators:

Use NIOSH/MSHA approved respirator appropriate for exposure of concern.

   Small Spill or Leak:

Evacuate area and ventilate.  Wear protective equipment.  If required, use an inert absorbent. Sweep up and place in an appropriate container for disposal.  Wash contaminated surfaces.

   Stability:

No data.

   Incompatibilities:

Strong oxidizing agents.

FIRE

   Fire Fighting:

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

HEALTH

   Exposure Effects - Inhalation:

Apnoea has developed secondary to seizures following overdose. - Pulmonary infiltrates with eosinophilia has occurred with chronic therapeutic use. Bronchoconstriction and asthma has been reported after initial dosing.

   Exposure Effects - Skin:

Photosensitivity and pseudo porphyria has been described in chronic therapeutic use. Necrotizing vasculitis has been reported with short term use.

   Exposure Effects - General:

CNS depression and seizures (focal and generalized) have occurred following overdose. A. Dizziness and dystonic movement disorders have also been reported. With therapeutic use - aseptic meningitis has been associated with naproxen.

The use of Naproxen should be avoided during pregnancy as insufficient studies have been performed. Because of known effects on the foetus (closure of ductus arteriosus), it should certainly be avoided during late pregnancy.

Naproxen has been found in the milk of lactating women; however, The American Academy of Paediatrics considers naproxen to be compatible with breast feeding (Briggs et al, 1998).

   First Aid - Ingestion:

Seek medical attention.  If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down.  Contact a physician, medical facility, or poison control centre for advice about whether to induce vomiting. If possible, do not leave individual unattended.

   First Aid - Inhalation:

If symptoms develop, move individual away from exposure and into fresh air.  If symptoms persist, seek medical attention.  If breathing is difficult, administer oxygen.  Keep person warm and quiet; seek immediate medical attention.

   First Aid - Skin:

Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.

   First Aid - Eyes:

If symptoms develop, immediately move individual away from exposure and into fresh air.  Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Stability and reactivity

See above

Disposal considerations

See above