Registration Dossier
Registration Dossier
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EC number: 248-470-8 | CAS number: 27458-93-1
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
No reliable guideline-standard measured bioconcentration studies are available. Based on the available predicted log Kow of 6.1 - 7.6 for the constituents, the substance could be considered to be potentially bioaccumulative. However, the rapid biodegradation of the substance (see section 5.2), combined with evidence of rapid metabolism in fish, mammals and micro-organism studies (Mankura (1987), and see Sections 7.1, 6.1.5), suggest that this would be an overly conservative interpretation, and that it is unlikely that bioaccumulation would be seen in studies. Furthermore, conducting guideline-standard studies of bioaccumulation in fish would be confounded by the technical difficulties of maintaining the test alcohols in solution. As was demonstrated in the long-term studies of effects in invertebrates (see IUCLID Section 6.1.2). Severe difficulties were encountered in conducting the study as biodegradation of the substance in the test system was almost complete within the 24 h test media renewal period.
BCF has been calculated using SRC BCFBAF v3.01 (EPA 2011). The model uses a log Kow-based equation with modified algorithms for specific structural features. The software also incorporates a modification for biotransformation in vivo which in an important property of the alcohols. Predicted BCF values of 680 - 1000 (depending on trophic level) for C14, 580 - 930 for C16 (linear and branched), 200 - 380 for C18 (linear and branched) and 44 - 85 for C20 (linear and branched) were determined.
However, it is evident that, even allowing for biotransformation, the predicted BCF values indicate a very significant overestimate compared to experimental values. For example, BCFBAF prediction for hexadecan-1-ol gives BCF values of 590 to 890, depending on trophic level, whereas there is non-guideline-standard measured BCF value of 60 available (Freitag et al., 1985).
Rapid biotransformation of C18 -unsaturated alcohol into tissue lipids has been demonstrated by Mankura (1987) in fish (carp).
The weight of evidence indicates that the constituents of Fatty alcohols C16 – C18 (even numbered), branched and linear,will not bioaccumulate.
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