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Diss Factsheets
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EC number: 701-363-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
There are no studies available for the determination of toxicokinetics or dermal absorption.
Propylidynetrimethanol, ethoxylated, esters with acrylic acid, reaction products with 1 -Butanamine, N-butyl- is a liquid with a molecular weight of app. 340 - 1180 g/mol, depending on the degree of ethoxylation, and a vapour pressure of 1.6 hPa at 20 °C. In agreement with its logPow of 3.5, up to 800mg can be dissolved in one liter of water.
Considering the physical chemical properties and the fact, that sensitization was observed in mice, dermal absorption of the test substance seems to be possible, though the molecular weight might be too high to favor dermal absorption for well ethoxylated molecules. For smaller molecules, the log PoW below 4 and a water solubility above .1 g/l will favor dermal absorption. Uptake might also be increased due to the irritant properties of the test substance, which might damage the skin barrier. Though the molecular weight and the log PoW allow for uptake via the oral route, no specific organ toxicity was observed in an repeated dose study. It is not clear, wether mortality in the high dose group was due to systemic effects or local irritation. Based on the moderate vapour pressure of 1.6hPa, inhalation exposure is also considered to be relevant.
No bioaccumulation is expected. No mutagenicity or chromosomal aberration was observed for the parent compound or the proposed metabolic products, so no reactivity with macromolecules is expected prior to excretion.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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