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Administrative data

Link to relevant study record(s)

Description of key information

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential

Additional information

There are no studies available for the determination of toxicokinetics or dermal absorption.

Propylidynetrimethanol, ethoxylated, esters with acrylic acid, reaction products with 1 -Butanamine, N-butyl- is a liquid with a molecular weight of app. 340 - 1180 g/mol, depending on the degree of ethoxylation, and a vapour pressure of 1.6 hPa at 20 °C. In agreement with its logPow of 3.5, up to 800mg can be dissolved in one liter of water.

Considering the physical chemical properties and the fact, that sensitization was observed in mice, dermal absorption of the test substance seems to be possible, though the molecular weight might be too high to favor dermal absorption for well ethoxylated molecules. For smaller molecules, the log PoW below 4 and a water solubility above .1 g/l will favor dermal absorption. Uptake might also be increased due to the irritant properties of the test substance, which might damage the skin barrier. Though the molecular weight and the log PoW allow for uptake via the oral route, no specific organ toxicity was observed in an repeated dose study. It is not clear, wether mortality in the high dose group was due to systemic effects or local irritation. Based on the moderate vapour pressure of 1.6hPa, inhalation exposure is also considered to be relevant.

No bioaccumulation is expected. No mutagenicity or chromosomal aberration was observed for the parent compound or the proposed metabolic products, so no reactivity with macromolecules is expected prior to excretion.