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EC number: 252-813-7 | CAS number: 35948-25-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Experimental work was carried out between 10.11.1997 and 18.11.1997
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Performed according to GLP, OECD guidelines followed and no deviations reported
- Justification for data waiving:
- other:
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Ukanol DOP
- IUPAC Name:
- Ukanol DOP
- Reference substance name:
- 6H-dibenz[c,e][1,2]oxaphosphorin 6-oxide
- EC Number:
- 252-813-7
- EC Name:
- 6H-dibenz[c,e][1,2]oxaphosphorin 6-oxide
- Cas Number:
- 35948-25-5
- Molecular formula:
- C12H9O2P
- IUPAC Name:
- 6H-dibenz[c,e][1,2]oxaphosphorin 6-oxide
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): Ukanol DOP
- Substance type: white powder
- Lot/batch No.: not supplied
- Storage condition of test material: Room temperature, darkness
- Other:
- Test article name for report: Ukanol DOP
- Test concentration: undiluted
- Arrival of test article: 06.11.1997
- Test article characterization (purity, solubility and stability etc.) was the responsibility of Sponsor according to available statement of 05.11.1997. The test article was labelled with the laboratory number of this study (Lab. No. 01438). The test result relates to the above mentioned test article supplied by Sponsor.
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: SPF albino
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Stock: Mol:Russian
- Source: Møllegaard Breeding and Research Centre A/S, Ejby, DK-4623 Lille Skensved
- Weight at study initiation: 2.1 - 2.4 kg
- Housing: The study took place in animal room No. 2. During a pre-period of at least one week and throughout the experiment the rabbits were caged individually in PPO cages (floor area: 2576 cm2) with perforated floor.
- Diet (e.g. ad libitum): A pelleted complete rabbit diet ''Altromin 2123'' from Altromin, D-32791 Lage, Lippe, was available ad libitum. Analyses for major nutritive components and relevant possible contaminants are performed regularly on the diet. Certificates of analysis are retained.
- Water (e.g. ad libitum): The animals had free access to bottles with domestic quality drinking water acidified with hydrochloric acid to pH 2.5 in order to prevent microbial growth. Analyses for relevant possible contaminants are performed regularly. Certificates of analysis are retained.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 ± 3
- Humidity (%): 55 ± 15 (relative humidity)
- Air changes (per hr): 10
- Photoperiod (hrs dark / hrs light): 12/12 (Light was on from 06 to 18 h)
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.1 ml of the test article
- Duration of treatment / exposure:
- Single application
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- Three females
- Details on study design:
- Testing procedure:
The day before testing both eyes of the animals were examined with a hand held inspection lamp fitted with white and UV-light and magnifying glass with 2 x magnification to ensure there were no defects or irritation. The examination was performed before and after instillation of Fluorescein. Only the left eye was treated. The right eye remained untreated and served as control.
0.1 ml of the test article was placed in the left eye of the rabbits by gently pulling the lower lid away from the eyeball to form a cup into which the article was dropped. The lids were then gently held together for 1 second. The eyes were examined and the grade of ocular reaction was recorded 1 and 24 hours later. After the first 24 hour reading Fluorescein was instilled. After rinsing with 20 ml 0.9% sodium chloride solution the eyes were examined again using UV-light to detect possible corneal damage. The eyes were also examined 48 and 72 hours as well as 7 days after the treatment. The reactions were scored according to the grades for ocular lesions outlined in the attached report.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 72h
- Score:
- 0.8
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 72h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 72h
- Score:
- 2
- Max. score:
- 3
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 72h
- Score:
- 1.1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
Any other information on results incl. tables
The individual results are shown in Table 1 of attached report.
- One hour after application of the test article all three rabbits showed diffuse redness of conjunctivae and discharge with moistening of lids and hairs and considerable area around the eye.
- After 24 hours animal No. 1002 showed slight opacity of cornea on less than the half of the area. With Fluorescein all animals showed slight opacity of cornea on less than the half of the area. Diffuse redness of conjunctivae and discharge with moistening of lids and hairs and considerable area around the eye were observed in all animals. Slight swelling of conjunctivae was observed in animal Nos. 1000 and 1002, whereas animal No. 1004 showed obvious swelling of conjunctivae.
- After 48 hours all animals showed slight opacity of cornea on less than the half of the area. With Fluorescein all animals showed slight opacity of cornea on less than a quarter of the area. Diffuse redness and slight swelling of conjunctivae were observed in all animals. Animal Nos. 1000 and 1002 showed discharge with moistening of lids and hairs and considerable area around the eye, animal No. 1004 showed discharge of lids and hairs just adjacent to lids.
- After 72 hours animal No. 1000 showed slight opacity of cornea on less than the half of the area. With Fluorescein all animals showed no comeal reactions. Furthermore all animals showed diffuse redness and slight swelling of conjunctivae as well as discharge of lids and hairs just adjacent to lids.
- After 7 days no eye reactions due to the application of the test article were seen.
The following mean values were obtained from the data presented in Table 1 of attached report:
cornea opacity 0.8
iris lesion 0.0
redness of conjunctiva 2.0
oedema of conjunctiva (chemosis) 1.1Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: other: According to the directive of the EEC commission 93/21/EEC of April 27, 1993
- Conclusions:
- According to the directive of the EEC commission 93/21/EEC of April 27, 1993 no classification is required for eye irritation for Ukanol DOP.
- Executive summary:
The eye irritant effect of Ukanol DOP was investigated according to the method recommended in the OECD Guideline No. 405, “Acute Eye Irritation/Corrosion”, Feb. 1987, and EEC Guideline B.5 “Acute Toxicity (Eye Irritation)”, 29.12.1992.
Three female albino rabbits were exposed to 0.1 ml of the test article in the left eye. The eyes were examined and the changes were graded according to a numerical scale 1, 24, 48 and 72 hours as well as 7 days after dosing.
Moderate signs of eye irritation were observed among the rabbits.
The following mean values, based on the results from the 24, 48 and 72 hour readings, were calculated:
Ukanol DOP
cornea opacity 0.8
iris lesion 0.0
redness of conjunctiva 2.0
oedema of conjunctiva (chemosis) 1.1
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