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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Old study, not to GLP, but similar to current guidelines

Data source

Reference
Reference Type:
publication
Title:
The Toxicity of Allylamines
Author:
Hine, CH et al
Year:
1960
Bibliographic source:
Archives of Environmental Health, Volume 1, Pages 343-352

Materials and methods

Principles of method if other than guideline:
Following OECD401 guideline, but using intraperitoneal dosing
GLP compliance:
no
Remarks:
Old study
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Allylamine
EC Number:
203-463-9
EC Name:
Allylamine
Cas Number:
107-11-9
Molecular formula:
C3H7N
IUPAC Name:
prop-2-en-1-amine
Test material form:
other: liquid
Details on test material:
Molecular weight: 57.09
Boiling point: 52.9 deg C
Melting point: -88.2 deg C
Flash point, tag open cup: -20 deg F
Specific Gravity, 20/4 C: 0.7627
Solubility in water, 20 deg C, %W: complete
pH of 0.1M aqueous solution: 11.2
ppm in 1 mg/mL: 429

Test animals

Species:
mouse
Strain:
other: Princeton
Sex:
male
Details on test animals or test system and environmental conditions:
Animals weighed 13-22 g

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
water
Details on exposure:
VEHICLE
- Concentration in vehicle: 1%
- Amount of vehicle (if gavage): Varies with dose level
Doses:
20, 40, 80 and 160 mg/kg
No. of animals per sex per dose:
5 males
Control animals:
no
Details on study design:
- Duration of observation period following administration: 10 days
- Frequency of observations and weighing:
- Necropsy of survivors performed: yes, where possible
Statistics:
LD50 calculated by method of Weil, 1952.

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
49 mg/kg bw
Based on:
test mat.
95% CL:
37 - 65
Mortality:
20 mg/kg: 0/5
40 mg/kg: 1/5 (4 days)
80 mg/kg: 5/5 (3-4 hours)
160 mg/kg: 5/5 (1-2 hours)
Clinical signs:
Decreased activity, but hyper-reaction to touch was observed after about one hour
Gross pathology:
Mice that died had congested lungs, livers and spleens, grossly, but no histologic change.

Applicant's summary and conclusion

Conclusions:
LD50 was 49 mg/kg (37-65)
Executive summary:

Mortality in male mice was:

20 mg/kg: 0/5

40 mg/kg: 1/5 (4 days)

80 mg/kg: 5/5 (3-4 hours)

160 mg/kg: 5/5 (1-2 hours)