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EC number: 420-640-8 | CAS number: 138495-42-8
Four groups of 20 male Crl:CD®BR rats per group and four groups of 20 female rats per group were exposed to atmospheres of the test substance vapour for 6 hours per day, 5 days per week, over a 90-day period at concentrations of 0, 500, 2000, or 3500 ppm. During the exposures, the concentration of the test substance was determined by gas chromatographic analysis of the chamber atmosphere. Ophthalmic examinations were conducted prior to initiation of exposures and after approximately 13 weeks of exposure. Body weights and food consumption were determined weekly. Evaluations of haematology, clinical chemistry, and urinalysis parameters were conducted at approximately 7 and 13 weeks. A functional observational battery (FOB) and assessment of motor activity (MA) were conducted on 10 rats per sex per concentration prior to initiation of the study. Similar evaluations were conducted at approximately 4, 8, and 13 weeks after initiation of exposure. Approximately 13 weeks after study initiation, all surviving rats designated for the subchronic toxicity subset (approximately 10 rats per sex per concentration) were necropsied, selected organs were weighed, and tissues were examined for gross and microscopic lesions. In addition, all surviving rats designated for the neurotoxicity subset (approximately 10 rats per sex per concentration) were necropsied and evaluated for morphological changes in nervous tissues.
The overall mean concentrations of the test substance in the exposure chambers for the 13-week test period were 0.0, 503.3, 1981.9, and 3472 ppm corresponding to the nominal concentrations of 0, 500, 2000, and 3500 ppm, respectively. A small amount (8.5 ppm) of the test substance was detected in the control chamber on test day 57 during one of the sampling intervals due to a small spill of the test substance in the chamber room.
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