Registration Dossier
Registration Dossier
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EC number: 420-640-8 | CAS number: 138495-42-8
Neurotoxicity
Administrative data
Description of key information
NOAEL = 15463 mg/m3 air
Key value for chemical safety assessment
Additional information
The adverse effects associated with the test substance were observed as transient or temporary impact on the central nervous system. The resulting symptoms were temporary convulsions and related central nervous system effects. These observations support the basis for treating all adverse effects (whether observed during acute or repeated inhalation exposures) as acute. The central nervous system effects behave in a concentration dependent manner, and do not increase in severity or occurrence with increasing time or repeated inhalation exposures. These observations are relevant for any hazard/risk assessment, since they demonstrate that the observed toxicity is associated with a concentration threshold, and is consistent across acute and repeated exposures. The NOAEL and LOAEL for neurotoxicity across the entire spectrum of acute and repeated inhalation exposures were 15463 and 20618 mg/m3, respectively.
Justification for classification or non-classification
Based on the high exposure concentrations necessary to produce adverse effects, and the observations during the acute and repeated exposure inhalation exposures, the substance does not need to be classified for neurotoxicity or specific toxicity according the EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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