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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1993
Report date:
1993

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient - HPLC Method)
GLP compliance:
yes
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
448-100-7
EC Name:
-
Cas Number:
70441-63-3
Molecular formula:
C9H12FN
IUPAC Name:
4-fluoro-N-(propan-2-yl)aniline
Test material form:
liquid

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
Key result
Type:
log Pow
Partition coefficient:
2.3
Temp.:
23 °C
pH:
5.59

Any other information on results incl. tables

Results

 

 

 

Volume

Concentration

Partition coefficient

Test number

pH value phase

Octanol phase (mL)

Water phase (mL)

Octanol phase (mg/mL)

Water phase (mg/mL)

Individual measurements

Average

1a

6.12

5.0

245

1.6037

0.00653

245.6

 

1b

6.05

5.0

245

1.6419

0.00745

220.4

233.0

2a

6.07

10.0

240

0.9038

0.00438

206.3

 

2b

6.28

10.0

240

0.8950

0.00430

208.1

207.2

3a

6.26

20.0

230

0.4691

0.00261

179.7

 

3b

6.11

20.0

230

0.4509

0.00252

178.9

179.3

 

Amount of test substance = 9.945 mg

Test temperature = 23°C

pH of water = 5.59

Partition coefficient P = 206 (average of three values)

Log P = 2.3

Sp (absolute standard deviation) = 25

Applicant's summary and conclusion