Registration Dossier

Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information


No information is available on the hydrolysis of hexadecyl 3,5-bis-tert-butyl-4-hydroxybenzoate. Since the substance is highly insoluble (< 10E-6 g/l at 20°C) the study is technically not feasible.


The substance is not readily biodegradable under aerobic conditions ( Mitsubishi Chemical Safety Institute, 1995). The aerobic transformation of [14C]hexadecyl 3,5-bis-tert-butyl-4-hydroxybenzoate in soil was studied in a GLP compliant study according to OECD 307 (Smithers Viscient, 2018). The rate and route of the transformation was studied in one representative soil, a sandy loam. [14C]hexadecyl 3,5-bis-tert-butyl-4-hydroxybenzoate degraded at a moderate rate over the incubation period under the conditions of this aerobic soil study, with a DT50 value of 117 days. No transformation products, except for 14CO2, have been identified during the study.


One experimental study is available indicating a low potential for bioaccumulation in aquatic organisms. BCF values of 15 and 36 were obtained in Cyprinus carpio after 60 d (Yakata, 2001). The substance does not fulfil the bioaccumulation trigger value of BCF > 2000 L/kg as given in ECHA Guidance, Chapter R.11, and does not fulfil the B- or vB-criterion.

Transport and distribution

In an OECD 121 test the measured Log Koc for hexadecyl 3,5 -bis-tert-butyl-4 -hydroxybenzoate was >5.63 (Koc >4.27E5).

Additional information