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EC number: 264-261-4 | CAS number: 63469-23-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
The toxicokinetic behaviour of the test substance is qualitatively assessed based on its physico-chemical parameters. The absorption factors were determined to be : oral 50%, dermal 50% and inhalation 100%.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 50
- Absorption rate - dermal (%):
- 50
- Absorption rate - inhalation (%):
- 100
Additional information
The test substance (CAS No 63469-23-8) is a liquid with a high water solubility (miscible), a moderate log Kow (0.0931 at pH 11.5; at physiological pH the substance will be charged and hence more hydrophilic) and a moderate vapour pressure (64 Pa). Its pKa is 10.2. The substance is found to be corrosive to the skin and the eyes.
No toxicokinetic data (animal or human studies) are available on this substance. The data present in this dossier are based on physico-chemical parameters and will allow a qualitative assessment of the toxicokinetic behaviour of the test substance.
Absorption
Oral/GI absorption
Following its high water solubility (100 g/L as limit value), the test substance will readily dissolve into the gastrointestinal fluids and subsequently pass through aqueous pores or be carried through the epithelial barrier by the bulk passage of water.
Based on its relatively low molecular weight (218 g/mole) and the moderate log Kow (0.0931), absorption by passive diffusion will be favoured.
The intestine is where absorption after oral administration is normally produced. Data on intestine pH for different species are rare and most stem from relatively old sources (ECHA guidance on IR&CSA, R.7c). Assuming a median intestinal pH value close to 7, the pKa of the test substance suggests that this substance will be predominantly in its ionized form at physiological pH. It is generally thought that ionized substances do not readily diffuse across biological membranes. Therefore it could be concluded that the diffusion across biological membranes of the test substance will be hampered.
The substance is corrosive and therefore it could enhance penetration by local necropsy of GI tissues.
The test substance has been tested in a subacute oral toxicity study (Combined repeated oral toxicity study with the reproduction/developmental toxicity screening test; OECD 422), a NOAEL of 100 mg/kg bw/d was derived.
In the gastro-intestinal tract hardly any degradation of the substance is to be expected. The oral absorption factor is set to 50%, based on the anticipated hampered diffusion of the test substance as an ionized substance. The results of the toxicity studies do not provide reasons to deviate from this proposed value.
Respiratory absorption
Given the vapour pressure of 64 Pa, the test substance is not a highly volatile substance and the availability for inhalation as a vapour is limited.
Once in the respiratory tract, the very hydrophilic substance may be retained within the mucus, and subsequently absorption may occur. Absorption directly across the respiratory tract epithelium by passive diffusion is favoured in view of the moderate log Kow value.
Based on the above considerations, the inhalatory absorption factor is set to 100%.
Dermal absorption
In view of its high water solubility and moderate log Kow, penetration into the lipid-rich stratum corneum and hence dermal absorption might be limited although its physical form (liquid) and relatively low molecular weight (218) favours dermal absorption.
As the test substance is a corrosive substance, absorption/penetration will be enhanced.
Generally default values of 10% and 100% are used for dermal absorption, based on molecular weight and log Kow value (ECHA guidance on IR&CSA, R.7c). The dermal absorption factor might therefore set to 100% (default), based on a molecular weight < 500 and a log Kow in the range of -1 to 4. However it is also generally acknowledged that dermal absorption will not be higher compared to oral absorption; as a result, the dermal absorption factor for the test substance set to 50%. The results of the toxicity studies do not provide reasons to deviate from this proposed value.
Distribution
The high water solubility and low molecular weight predict that the substance will distribute widely through the body.
The log Kow value was experimentally determined to be 0.0931 (Tarran D.A., 2012). This study was performed on the non-ionised form of the substance, at pH 11.5 and hence the log Kow under environmental / physiological conditions is anticipated to be lower due to ionisation at pH values below the pKa of the substance (10.2). The substance is not likely to distribute into cells and hence the intracellular concentration is not expected to be higher than the extracellular concentration.
Accumulation
In view of the low log Kow and the high water solubility, the test substance is not expected to accumulate in the body (lung, adipose tissue, stratum corneum).
Metabolism
Once absorbed, extensive hydroxylation (aliphatic carbons) and oxidative deamination (tertiary amines), followed by rapid sulfation or glucuronidation is expected.
Excretion
Given the high water solubility and relatively low molecular weight, the test substance and its metabolites will be mainly excreted via the urine.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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