Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

 The acute toxicity of trans-N1,N1,N4,N4-Tetrakis(2-hydroxyethyl)1,4-cyclohexanedicarboxamide was examined. After oral application the LD50 for rats was found to be > 2000 mg/kg bw. The acute inhalation LC50 for rats was found to be > 5.07 mg/L .

Key value for chemical safety assessment

Additional information

Studies in Animals:

Oral

After oral application the LD50for rats was found to be > 2000 mg/kg bw in a test performed according to OECD Guideline 423. No signs of toxicity were observed. No animal died prematurely.

Inhalation:

After exposition via inhalation (dust) the LC50 for rats was found to be > 5.07 mg/L bw in a test performed according to OECD Guideline 403. The animals showed slight ataxia and slight dyspnoea. No animal died prematurely. No pathological findings were noted at necropsy. One of the 3 female animals appeared to be reduced in body weight gain.

Justification for classification or non-classification

According to the criteria of EC Directive 67/548/EEC and EC Regulation 1272/2008 and subsequent regulations on classification, labelling and packaging of substances and mixtures and based on the results of the studies trans-N1,N1,N4,N4-Tetrakis(2-hydroxyethyl)1,4-cyclohexanedicarboxamide is not classified.