3-Thiophenecarboxylic acid, tetrahydro-5-methyl-4-oxo-, methyl ester

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Test procedure in accordance with national standard methods with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2007

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

no data

GLP compliance:

no

Test type:

other: ACUTE ORAL TOXICITY SCREENING IN THE RAT

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

methyl 5-methyl-4-oxothiolane-3-carboxylate

EC Number:

619-801-7

Cas Number:

66319-07-1

Molecular formula:

C7H10O3S

IUPAC Name:

methyl 5-methyl-4-oxothiolane-3-carboxylate

Test animals

Species:

rat

Strain:

not specified

Sex:

female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

other: methylcellulose

Doses:

10 ml/kg

No. of animals per sex per dose:

3

Control animals:

no

Results and discussion

Effect levels

Sex:

female

Dose descriptor:

LD50

Effect level:

> 300 mg/kg bw

Based on:

test mat.

Mortality:

At 300 mg/kg/body weight, no mortality were observed.

Clinical signs:

other: At 300 mg/kg/body weight, no clinical signs were observed.

Applicant's summary and conclusion

Interpretation of results:

harmful

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The LD50 for acute oral toxicity with the test item in the female rat was found to be more than 300 mg/kg body weight.