Registration Dossier
Registration Dossier
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EC number: 203-242-7 | CAS number: 104-83-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Animals tested were all females ca. 14 weeks old and had an average weight at the beginning of the test of 161 g. The rats tested were kept in groups of 5 under following conditions: 22 +/- 1.5 °C; 12 h light/dark cycle; humidity 60 +/- 5%
Food (Altromin R 1324) and tap water were provided at libitum during the entire test period.
Duration of observation: 14 days. - GLP compliance:
- no
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- α,4-dichlorotoluene
- EC Number:
- 203-242-7
- EC Name:
- α,4-dichlorotoluene
- Cas Number:
- 104-83-6
- Molecular formula:
- C7H6Cl2
- IUPAC Name:
- 1-chloro-4-(chloromethyl)benzene
- Details on test material:
- p-Chlorobenzyl chloride, solid.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Test animals:
Wistar rats, females, ca. 14 weeks old. Average weight at the beginning of the test: 161 g.
Tested in groups of 5 animals. Conditions: 22 +/- 1.5°C; 12h light/dark cycle; humidity 60 +/- 5%
Source: Winkelmann, Borchen
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- polyethylene glycol
- Details on oral exposure:
- The test substance was composited with Lutrol (polyethylene glycol) and administered by gavage.
The mixture was given once. - Doses:
- 100, 500, 800, 900, 1000, 1500 mg/kg bw
- No. of animals per sex per dose:
- 10
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 786 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Conclusions:
- The LD50 value for acute oral toxicity is 786 mg/kg bw in female Wistar rats.
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