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Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2011-09-19 to 2011-09-26
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2011
Report date:
2011

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method

Test material

Constituent 1
Chemical structure
Reference substance name:
ethyl 3-[(pyridin-2-yl)amino]propanoate
EC Number:
600-382-4
Cas Number:
103041-38-9
Molecular formula:
C10 H14 N2 O2
IUPAC Name:
ethyl 3-[(pyridin-2-yl)amino]propanoate

Results and discussion

Water solubility
Water solubility:
6.7 g/L
Conc. based on:
test mat.
Loading of aqueous phase:
20 mg/L
Incubation duration:
>= 48 - <= 96 h
Temp.:
20 °C
pH:
7.02
Remarks on result:
other: about 2 g of test item/ 100 mL of water analytical grade

Applicant's summary and conclusion

Conclusions:
From the experimental data obtained according to CIPAC methods MT 157, the guideline A.6 in Official Journal L 383 Part A and OECD Guideline No. 105, it can be concluded that the water solubility of BIBR 1048 Ester sample is 6.7 g/L at 20°C.