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EC number: 278-145-6 | CAS number: 75234-41-2
After single occlusive exposure of intact as well as abraded clipped skin for 24 hours with 500 mg of moistened test material per site none of 6 animals showed irritation reactions. Neither erythemas nor edemas were observed at any treated site. The instillation of 100 mg of the solid analogous substance produced positive effects in the conjunctivae of the 3 animals 1 and 24 hours after treatment. The test article was regarded as a mild irritant to the rabbit eye but the effects were not sufficient for classification.
After single occlusive exposure of intact as well as abraded clipped skin for 24 hours with 500 mg of moistened test material per site none of 6 animals showed irritation reactions. Neither erythema nor edema were observed at any treated site.
A study was performed to assess the irritant effects of the test material on the eye of the New Zealand White rabbit. The protocol was designed to meet the requirements of Annex Vof the EEC Council Directive 79/831/EEC, the Organisatfon for Economic Co-operation and Development (OECD) and the HSE Approved Code of Practice Notification of New Substances Regulations 1982.
The instillation of 100 mg of solid Brown HH 469 produced positive eye effects in the conjunctivae of the 3 animals one and 24 hours after treatment. The test article was regarded as a mild irritant to the rabbit eye.
No irritant effects were observed after dermal application of the test item for 24 hours. Ocular application produced slight transient irritation of the conjunctivae. Recovery was achieved within 2 days. Effects were not sufficient for classification.
Classification is not needed as the criteria are not fulfilled, neither after dermal nor after ocular treatment. The slight ocular effects were not sufficient for classification.
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