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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
Data is from study report
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Principles of method if other than guideline:
The Partition coefficient n-octanol/water of test chemical has been determined by the Reverse Phase High performance Liquid Chromatographic Method according to OECDS guidelines for testing of chemicals ,Method No.117
GLP compliance:
not specified
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
4.1
Temp.:
24
Remarks on result:
other: The value indicates that chemical is Hydrophobic in naure
Conclusions:
The Partition coefficient n-octanol/water of test chemical has been determined by the Reverse Phase High performance Liquid Chromatographic Method according to OECDS guidelines for testing of chemicals ,Method No.117 the Log kow value was determined to be 4.1.
Executive summary:

The Partition coefficient n-octanol/water of test chemical has been determined by the Reverse Phase High performance Liquid Chromatographic Method according to OECD guidelines for testing of chemicals, Method No.117 the Log kow value was determined to be 4.1 at 24 degree C.

Description of key information

The Partition coefficient n-octanol/water of test chemical has been determined by the Reverse Phase High performance Liquid Chromatographic Method according to OECD guidelines for testing of chemicals, Method No.117 the Log kow value was determined to be 4.1 at 24°C.On the basis of this value the test chemical is considered to be hydrophilic in nature.

Key value for chemical safety assessment

Log Kow (Log Pow):
4.1
at the temperature of:
24 °C

Additional information

In a key study from experimental study report, the Partition coefficient n-octanol/water of test chemical has been determined by the Reverse Phase High performance Liquid Chromatographic Method according to OECD guidelines for testing of chemicals, Method No.117 the Log kow value was determined to be 4.1 at 24°C.

In a supporting study, the Partition coefficient (Pow) of test chemical at 25°C was determined according to the OECD Guideline No. 107,”Shake Flask Method”. In this method the different volumes of a stock solution (n-octanol pre saturated with water) were shaken with different volume of water pre saturated with n-octanol. After centrifugation, both the aqueous phase and octanol phase were analysed by HPLC. The partition coefficient were calculated, from the measured concentration of test chemical in the organic and aqueous phases.The log Pow value was determined to be 3.802± 0.001 at 25°C temperature.