Registration Dossier
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EC number: 238-883-1 | CAS number: 14814-09-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1995-09-26 to 1995-09-28
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: 0.64, 1.3, 2.7, 5.4, 11, 21 and 43 mg/l and the fresh stock solution used to prepare the test media.
- Sampling method: Concentrations of test substance hydrolysis products determined in fresh media at all concentrations after preparation and again before renewal after 24 hours. The concentrations of the fresh stock solution used to prepare the test media was also determined.
- Sample storage conditions before analysis: not reported - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: Test media prepared by dilution of a 1000 mg/l stock solution prepared by mixing for 18 h followed by filtration. TOC concentration of stock solution determined and used as the basis for determining the nominal test concentrations.
- Test concentrations (Nominal): Control, 0.64, 1.3, 2.7, 5.4, 11, 21 and 43 mg/l - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna
- Strain: Clone 5
- Source: Stock culture
- Age at study initiation (mean and range, SD): <24 h
- Method of breeding: Parthenogenetic reproduction
- Feeding during test: None
ACCLIMATION
- Acclimation conditions (same as test or not): yes
- Type and amount of food: sufficient to be consumed each day leaving no residue
- Feeding frequency: daily - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- The sum of the Ca2+ and Mg2+ ions: 2.5 mmol
- Test temperature:
- 20 +/-1 degree C
- pH:
- 7.5 - 7.9
- Dissolved oxygen:
- 8.8 - 9.6 mg/l
- Salinity:
- not applicable
- Nominal and measured concentrations:
- - Test concentrations (Nominal): Control, 0.64, 1.3, 2.7, 5.4, 11, 21 and 43 mg/l
- Test concentrations (at start of test): Control,
- Test concentrations at end of test: Control,
- The measured concentrations that were >LOD were within +/-20% of nominal. The results are therefore presented and interpreted with reference to nominal concentrations. - Details on test conditions:
- TEST SYSTEM
- Test vessel: glass cylinder
- Type: open
- Material, size, headspace, fill volume: cylinder containing 10 ml of test medium
- Aeration: none
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Elendt M4 medium
- Intervals of water quality measurement: end of test
OTHER TEST CONDITIONS
- Photoperiod: Dark
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : Immobilization after 24 and 48 h exposure
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 2 - Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 6.7 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- but exposure is to hydrolysis products
- Basis for effect:
- mobility
- Remarks on result:
- other: 4.9 - 9.1
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 20 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- but exposure is to hydrolysis products
- Basis for effect:
- mobility
- Remarks on result:
- other: 12 - 36
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 2.7 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- but exposure is to hydrolysis products
- Basis for effect:
- mobility
- Results with reference substance (positive control):
- - Results with reference substance valid?
- EC50/LC50: >1 mg/l, <2.0 mg/l - Reported statistics and error estimates:
- EC50 and confidence interval determined by Probit analysis
- Validity criteria fulfilled:
- yes
- Conclusions:
- A 48-h EC50 value of 6.7 mg/l and a NOEC of 2.7 mg/l have been determined for the effects of the test substance on mobility of Daphnia magna based on nominal concentrations of the substance. The test substance is susceptible to hydrolysis and it is therefore likely that the test organisms were primarily exposed to the hydrolysis products of the substance. The EC50 is equivalent to 5.3 mg/l when expressed in terms of the silanol hydrolysis product, 3-mercaptopropylsilanetriol.
Reference
Table 1. Results of analysis of test media
Nominal test concentration (mg/l) | Measured concentration at start of test (mg/l) | Measured concentration at end of test (mg/l) |
0 (Control) | - | - |
0.64 | <LOD | <LOD |
1.3 | <LOD | <LOD |
2.7 | Unreliable value | 2.3 |
5.4 | Unreliable value | 6.3 |
11 | 12.4 | 9.7 |
21 | 20.9 | 20.4 |
43 | 37.7 | 39.8 |
Table 2. Test results
Nominal test concentration (mg/l) | Mean percentage immobilisation after 24 hours | Mean percentage immobilisation after 48 hours |
0 (Control) | 5 | 5 |
0.64 | 0 | 0 |
1.3 | 0 | 0 |
2.7 | 0 | 5 |
5.4 | 15 | 50 |
11 | 50 | 85 |
21 | 40 | 90 |
43 | 70 | 95 |
Description of key information
No data are available for 3-(triethoxysilyl)propanethiol (CAS 14814-09-6). However a 48-hour EC50 value of 6.7 mg/l has been read-across for the effects of the read-across substance 3-(trimethoxysilyl)propane-1-thiol (CAS 4420-74-0) on mobility in Daphnia magna. The EC50 is equivalent to 5.3 mg/l when expressed in terms of the silanol hydrolysis product, 3-(trihydroxysilyl)propanethiol.
A stepwise testing strategy is proposed to address the requirements of the ECHA decision letter (TPE-D-2114432420-65-01/F). Please refer to the attachment in IUCLID Section 13. This read-across is retained as an interim measure to calculate a PNEC and support the existing chemical safety assessment until new evidence becomes available.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 6.7 mg/L
Additional information
There are no reliable short-term invertebrate toxicity data available for 3-(triethoxysilyl)propanethiol (CAS 14814-09-6), therefore good quality data for an appropriate structural analogue, 3-(trimethoxysilyl)propane-1-thiol (CAS 4420-74-0) have been read across. Both substances hydrolyse to the same hydrolysis product, 3-(trihydroxysilyl)propanethiol. Both substances have hydrolysis half-lives which indicate that, under conditions relevant to ecotoxicity assessment, both will partially hydrolyse to 3-(trihydroxysilyl)propanethiol over the course of the test. The other hydrolysis products are ethanol and methanol respectively; the properties of these substances are well characterised. Methanol is non-toxic to the environment and it is considered unlikely that its presence significantly affected the results of the test performed with the parent substance.
A 48-hour EC50 value of 6.7 mg/L has been determined for the effects of 3-(trimethoxysilyl)propane-1-thiol (CAS 4420-74-0) on the mobility of Daphnia magna based on nominal concentrations of the substance (Hüls, 1995). The result was obtained under static test conditions. In view of the test media preparation method and exposure regime, it is likely that the test organisms were exposed predominantly to the hydrolysis products of the tested substance.
The results may be expressed in terms of the concentration of the hydrolysis product, 3-(trihydroxysilyl)propanethiol, by applying a molecular weight correction (MW of silanol = 154.26 / MW of parent = 196.34) * (concentration of parent = 6.7 mg/L) = 5.3 mg/L.
The study was considered to be reliability 1 (reliable without restrictions)
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