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Reliable short-term toxicity test results are available for freshwater fish (Danio rerio), invertebrates (Daphnia magna) and algae (Pseudokirchneriella subcapitata) for the registered substance, 3-(triethoxysilyl)propanethiol (CAS 14814-09-6, EC No. 238-883-1):

Fish (96 h): LC50 = >2.55 mg/l. This is equivalent to >1.65 mg/l when expressed in terms of the silanol hydrolysis product, 3-(trihydroxysilyl)propanethiol.

Invertebrates (48 h): EC50 = 2.71 mg/l. This is equivalent to 1.75 mg/l when expressed in terms of the silanol hydrolysis product, 3-(trihydroxysilyl)propanethiol.

Algae (72 h): ErC50 = 32.2 mg/l, ErC10 = 11.8 mg/l and NOErC = 4.8 mg/l. These values are equivalent to 20.8, 7.6 and 3.1 mg/l when expressed in terms of the silanol hydrolysis product, 3-(trihydroxysilyl)propanethiol.

A reliable long-term toxicity to Daphnia magna test result is also available with the registered substance:

A 21-day NOEC value of 0.081 mg/l has been determined for the effects of the test substance (3-(triethoxysilyl)propanethiol (CAS 14814-09-6, EC No. 238-883-1)) on survival and reproduction of Daphnia magna, based on time weighted average measured concentrations of the parent substance.

An activated sludge respiration inhibition 3 hour EC50 463 mg/l and EC10 32.6 mg/l were determined in a reliable study with the read-across substance, 3-(trimethoxysilyl)propane-1-thiol (CAS 4420-74-0).

Supporting data have been read across from 3-(trimethoxysilyl)propane-1-thiol (CAS 4420-74-0,EC No. 224-588-5), to support the existing chemical safety assessment and calculate indicative PNECs for the silanol hydrolysis product. Both the registered substance and the read-across substance hydrolyse to 3-(trihydroxysilyl)propanethiol.

Reliable short-term toxicity test results are available for freshwater fish (Danio rerio), invertebrates (Daphnia magna) and algae (Desmodesmus subspicatus), read across from 3-(trimethoxysilyl)propane-1-thiol (CAS 4420-74 -0, EC No. 224-588-5):

Fish (96 h): LC50 = 439 mg/l. This is equivalent to 345 mg/l when expressed in terms of the silanol hydrolysis product, 3-(trihydroxysilyl)propanethiol.

Invertebrates (48 h): EC50 = 6.7 mg/l. This is equivalent to 5.3 mg/l when expressed in terms of the silanol hydrolysis product, 3-(trihydroxysilyl)propanethiol.

Algae (72 h): ErC50 = 931 mg/l, ErC10 = 92 mg/l and NOErC = 40 mg/l. These values are equivalent to 731, 72 and 31 mg/l when expressed in terms of the silanol hydrolysis product, 3-(trihydroxysilyl)propanethiol.

 

Refer to IUCLID Section 6 endpoint summary (CSR Section 7.0) for further discussion of the approach to chemical safety assessment and justification for read across.