Registration Dossier
Registration Dossier
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EC number: 271-591-2 | CAS number: 68585-82-0
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- the study does not need to be conducted because the substance is highly insoluble in water
- Justification for type of information:
- JUSTIFICATION FOR DATA WAIVING
See the link in the 'Cross-reference' table.
Cross-reference
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 10 April - 21 June 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 2008
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Version / remarks:
- 1998
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- column elution method
- Water solubility:
- < 0.522 µg/L
- Conc. based on:
- other: Yttrium
- Temp.:
- 20 °C
- pH:
- >= 6.9 - <= 7
- Key result
- Water solubility:
- < 0.663 µg/L
- Conc. based on:
- other: Yttrium Oxide (Y2O3)
- Temp.:
- 20 °C
- pH:
- >= 6.9 - <= 7
- Details on results:
- Turbidity of the eluates was <0.2 NTU, thus no undissolved particles were detected in the eluates.
In all samples, a small Yttrium response was detected. This response was below the lowest calibration solution.
<0.522 µg/L yttrium was analysed at 12 and 24 ml/h flow rate with a pH of 6.9 and 7.0 respectively, with 0.5 µg/L being the lowest calibration solution. This is equivalent to < 0.663 µg/L yttrium oxide concentration.
The test substance signal in the samples from the blank column was below that of the lowest calibration standard. - Conclusions:
- The substance is insoluble in water. In a study according to current OECD/EC/EPA test guidelines, the water solubility was determined using the column elution method resulting in a water solubility of <0.663 µg/L, expressed as Yttrium Oxide (Y2O3).
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
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