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EC number: 215-553-5
CAS number: 1330-86-5
No experimental data evaluating the toxicity to sediment organisms is
available for the category PFAE linear. Since all members of the
category are readily biodegradable, chronic exposure of sediment
organisms is unlikely. In addition, available data indicate, that
members of the PFAE linear are not bioaccumulative. Based on the
available information, toxicity to sediment organisms is not expected to
be of concern.
Intrinsic properties and fate/ exposure
All members of the PFAE linear category are readily biodegradable. According
to the Guidance on information requirements and chemical safety
assessment, Chapter R.7b, readily biodegradable substances can be
expected to undergo rapid and ultimate degradation in most environments,
including biological Sewage Treatment Plants (STPs) (ECHA, 2012b).
Therefore, after passing through conventional STPs, only low
concentrations of these substances are likely to be (if at all) released
into the environment.
Aquatic ecotoxicity data
The PFAE linear is a robust category with sufficient experimental data
for the aquatic toxicity covering acid carbon numbers from C6 to C10 and
total carbon numbers ranging from C10 to C38. Short-term aquatic
toxicity data is available for all trophic levels within the PFAE linear
category. Long-term data is available for aquatic invertebrates and
algae. Based on the experimental data, the majority of category members
exhibit no acute and chronic toxicity to aquatic organisms, up to the
limit of water solubility. Only two esters with Adipic acid (C6) as
dicarboxylic acid component and short chain alcohols, were observed to
exhibit ecotoxicological effects (CAS 105-99-7, Dibutyl adipate and CAS
6938-94-9, Diisopropyl adipate).
After absorption, members of the PFAE linear category are expected to be
enzymatically hydrolysed in vivo by the ubiquitary enzyme
carboxylesterase, yielding the corresponding alcohols and dicarboxylic
acid. QSAR estimations using BCFBAF v3.0 support the expected rapid
biotransformation of this substance with BCF/BAF values of < 29 L/kg,
respectively (Arnot-Gobas estimation including biotransformation, upper
The metabolism of the hydrolysis products: alcohol (e.g. Isopropanol)
and dicarboxylic acid (e.g. Adipic acid) is well established and not of
concern in terms of bioaccumulation (for further information see chapter
5.3 of the technical dossier).
Due to its readily biodegradable nature, extensive degradation of all
members of the PFAE linear category in conventional STPs will take place
and only low concentrations are expected to be released (if at all) into
the environment. After uptake by sediment species, extensive and fast
biotransformation of these substances by carboxylesterases into
dicarboxylic acids and the corresponding alcohol is expected. The
supporting BCF/BAF values estimated with the BCFBAF v3.01 program,
Arnot-Gobas model including biotransformation, also indicate that
members of the PFAE linear category will not be bioaccumulative.
Therefore, all members of the PFAE linear category are unlikely to pose
a risk for sediment organisms in general and testing is thus omitted.
A detailed reference list is provided in the technical dossier (see
IUCLID, section 13) and within CSR.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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