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Description of key information

NOEC (3h) >= 350 mg/L (nominal) for respiration inhibition of activated sludge (OECD 209)

Key value for chemical safety assessment

Additional information

No studies investigating the toxicity of Diisooctyl adipate (CAS 1330-86-5) to aquatic microorganisms are available. Therefore, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 Grouping of substances, a read-across to the structurally related category members Bis(2-ethylhexyl)adipate (CAS 103-23-1) and Diisononyl adipate (CAS 33703-08-1) was conducted. Further justification is given within the endpoint summary 6.1 and within the category justification section 13.In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance within this category was used.

The test with Bis(2-ethylhexyl)adipate (CAS 103-23-1) was conducted according to EU Method C.11 using activated sludge (BASF, 1986). No adverse effects on respiration were observed at 350 mg/L. Therefore, the NOEC (3h) is assessed as >= 350 mg/L (nominal) and the EC50 (3) > 350 mg/L.

The test with Diisononyl adipate (CAS 33703-08-1) was conducted according to ISO 8192 using domestic, activated sludge as test organism (BASF, 1990).Test concentrations of 1001.2, 498.4 and 198.8 mg/L were applied. The E20 (0.5h) was calculated as > 1000 mg/L (nominal), based on respiration inhibition.

Due to structural and property similarities to the analogue substances Diisononyl adipate (CAS 33703-08-1) and Bis(2-ethylhexyl)adipate (CAS 103-23-1) these results are also applicable to read across to Diisooctyl adipate (CAS 1330-86-5).

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