Registration Dossier
Registration Dossier
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EC number: 215-553-5 | CAS number: 1330-86-5
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No adverse effects up to the limit of water solubility (< 0.05 mg/L in aqua dest) for aquatic invertebrates
Key value for chemical safety assessment
Additional information
No studies investigating the long-term toxicity of Diisooctyl adipate (CAS 1330-86-5) to aquatic invertebrates are available. Therefore, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 Grouping of substances, a read-across to the structurally related category members Bis(2-ethylhexyl)adipate (CAS 103-23-1) and Diisononyl adipate (CAS 33703-08-1) was conducted. Further justification is given within the endpoint summary 6.1 and within the category justification section 13.In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance within this category was used.
Two studies are available for Bis(2-ethylhexyl)adipate (CAS 103-23-1). One test was conducted under semi-static conditions according to OECD 211 using Daphnia magna as test organism (MOE, 2000). A mixture of DMF and HCO-40 was used as vehicle at a concentration of 100 mg/L. Test concentrations of 5.0, 16 and 50 mg/L (nominal) were applied. The NOErC (21d) is assessed as 16 mg/L (nominal) and 14 mg/L (measured).
The second test with Bis(2-ethylhexyl)adipate (CAS 103-23-1) was conducted under similar conditions but with MARLOWET R 40 as vehicle. Test concentrations of 0.5, 1.0, 2.0 mg/L (nominal) were applied. No effects on reproduction were observed. The NOErC (21d) is assessed as >= 2 mg/L (nominal) and >= 0.77 mg/L (measured).
The test with Diisononyl adipate (CAS 33703-08-1) was conducted under semi-static conditions similar to OECD 211 (Williams, 1983). Acetone was used as vehicle at a concentration of 100 mg/L. Test concentrations of 3.2, 10, 32 and 100 µg/L were applied. No NOEC calculation was performed, however as the number of offspring is similar or even higher than the highest test substance concentration, a NOErC of >= 0.1 mg/L can be assumed.
Due to structural and property similarities to the analogue substances Diisononyl adipate (CAS 33703-08-1) and Bis(2-ethylhexyl)adipate (CAS 103-23-1) these results are also applicable to read across to Diisooctyl adipate (CAS 1330-86-5).
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