Registration Dossier

Diss Factsheets

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

No toxic effects up to the limit of water solubility (< 0.05 mg/L in aqua dest) for aquatic invertebrates

Key value for chemical safety assessment

Additional information

No studies investigating the short-term toxicity of Diisooctyl adipate (CAS 1330-86-5) to aquatic invertebrates are available. Therefore, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 Grouping of substances, a read-across to the structurally related category members Bis(2-ethylhexyl)adipate (CAS 103-23-1) and Diisononyl adipate (CAS 33703-08-1) was conducted. Further justification is given within the endpoint summary 6.1 and within the category justification section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance within this category was used.

The test with Bis(2-ethylhexyl)adipate (CAS 103-23-1) was conducted under semi-static conditions according to OECD 202 using Daphnia magna as test organism (MOE, 2000). A mixture of DMF and HCO-40 was used as vehicle at a concentration of 100 mg/L. Only one test concentration was applied (50 mg/L nominal, 48 mg/L measured). No immobilization was observed. Therefore, the EC50 (48h) is assessed as > 50 mg/L (nominal) and > 48 mg/L (measured).

The test with Diisononyl adipate (CAS 33703-08-1) was conducted under static conditions similar to OECD 202 using Daphnia magna as test organism (BASF, 1990). Cremophor RH was used as vehicle at a concentration of 100 mg/L. Test concentrations of 0.049, 0.098, 0.195, 0.39, 0.78, 1.56, 3.13, 6.25, 12.5, 25, 50 and 100 mg/L were directly added to the test vessels. The EC50 (48h) was calculated as > 100 mg/L, based on nominal concentration. 

Due to structural and property similarities to the analogue substances Diisononyl adipate (CAS 33703-08-1) and Bis(2-ethylhexyl)adipate (CAS 103-23-1) these results are also applicable to read across to Diisooctyl adipate (CAS 1330-86-5).