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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

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Classification & Labelling & PBT assessment

PBT assessment

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Administrative data

PBT assessment: overall result

PBT status:
the substance is not PBT / vPvB

The PBT Assessment for Diisooctyl adipate (CAS 1330-86-5) is based on the criteria set out in the “Guidance on information requirements and chemical safety assessment, Chapter R.11: PBT Assessment” (ECHA, 2012).


Diisooctyl adipate (CAS 1330-86-5) is considered to be readily biodegradable. This assumption is based on a study conducted according to OECD 301F (70.2% (O2 consumption) after 28 d). Thus, the test substance does not meet the screening criterion for persistence and it is not considered to be P or vP.


The bioaccumulation potential of Diisooctyl adipate (CAS 1330-86-5) is expected to be low. This assumption is based on a low bioavailability of the substance due to its ready biodegradability and low water solubility. Furthermore the substance is rapidly metabolised and excreted by organisms and thus an accumulation is not expected. This is supported by calculated low BCF/BAF values (BCF = 4.79 L/kg, BAF = 5.25 L/kg; Arnot-Gobas estimate, upper trophic). Thus the substance is not considered to be B or vB.


Diisooctyl adipate (CAS 1330-86-5) is considered to be not toxic. The assessment is based on a read across to the structurally similar substance Bis(2-ethylhexyl)adipate (CAS 103-23-1). In a study on the long-term toxicity of Bis(2-ethylhexyl)adipate (CAS 103-23-1) to Daphnia magna a NOErC (21d) > 50 mg/L (nominal) and > 48 mg/L (measured) was recorded. Furthermore the substance is not classified according to Directive 67/548/EEC and Regulation (EC) No. 1272/2008. Thus, the criteria set out in Annex XIII of Regulation (EC) No. 1907/2006 are not met and the substance is considered to be not T.