Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

No animal or human data available; due to the corrosive properties to the skin, it is not considered ethical to perform a skin sensitisation test in animals. QSAR data demonstrate, that a skin sensitising potential cannot be excluded.

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (sensitising)
Additional information:

Sensitisation

There is no skin sensitisation test for 1-ethylpiperazine available and due to the corrosive properties to the skin, it is not considered ethical to perform a skin sensitisation test in animals. QSAR studies (Toolbox and TIMES, 2018) for 1 -ethylpiperazine, CSA 5308 -25 -8 does not exclude a skin sensitising potential.

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

Due to the available QSAR data 1 -ethylpiperazine in considered to be skin sensitising according to regulation (EC) No.1272/2008 and is classified for skin sensitisation Cat. 1B.