Registration Dossier

Administrative data

Endpoint:
carcinogenicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
not reported
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Secondary source with no methodological information. Read across from dimethyltin bis(2-ethylhexylthioglycolate) + monomethyltin tris(2-ethylhexylthioglycolate)

Data source

Reference
Reference Type:
review article or handbook
Title:
Ecological and Toxicological Aspects of Mono and Disubstituted Methyl-, Butyl-, Octyl-, and Dodecyltin Compounds - Update 2002
Author:
Summer K.H., Klein, D. & Greim, H.
Year:
2003
Bibliographic source:
Primary Source: Mosinger M., Centre D’Explotations et de Recherches Medicales, Marseille (1975). Final Report Advastab TM 181 FS (Cincinnati-Milacron)

Materials and methods

Principles of method if other than guideline:
No methodological information available.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: crystalline
Details on test material:
- Name of test material (as cited in study report): dimethyltin bis(2-ethylhexylthioglycolate) + monomethyltin tris(2-ethylhexylthioglycolate)

Test animals

Species:
rat
Sex:
male/female

Administration / exposure

Route of administration:
oral: feed
Duration of treatment / exposure:
Two years
Doses / concentrations
Remarks:
Doses / Concentrations:
100 ppm
Basis:

No. of animals per sex per dose:
Twenty

Results and discussion

Results of examinations

Details on results:
dimethyltin dichloride: methyltin trichloride (72:28% mixture)

Applicant's summary and conclusion

Conclusions:
No malignant tumours were reported in in animals dosed with 100 ppm dimethyltin bis(2-ethylhexylthioglycolate) + monomethyltin tris(2-ethylhexylthioglycolate) for two years as compared to 8/164 in control animals.
Executive summary:

Twenty male and female rats were dose with 100 ppm dimethyltin bis(2-ethylhexylthioglycolate) + monomethyltin tris(2-ethylhexylthioglycolate) for 2 years in a feeding study. No further information is available.

No malignant tumours were reported in animals dosed with 100 ppm dimethyltin bis(2-ethylhexylthioglycolate) + monomethyltin tris(2-ethylhexylthioglycolate) for two years as compared to 8/164 in control animals.