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EC number: 212-039-2 | CAS number: 753-73-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
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- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
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- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 29 January 1993 - 12 April 1993
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Deviations:
- yes
- Principles of method if other than guideline:
- The temperature and relative humidity of the animal room (66-72 °F and 30-60 %, respectively) exceeded the range specified in the protocol (61-70°F and 40-60%, respectively) during this study. The final body weight and method of euthanasia was not recorded for animal #6636/M and #6640/M, respectively. These occurrences are considered to have had no adverse effect on the outcome of this study.
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Dimethyltin dichloride
- EC Number:
- 212-039-2
- EC Name:
- Dimethyltin dichloride
- Cas Number:
- 753-73-1
- Molecular formula:
- C2H6Cl2Sn
- IUPAC Name:
- dimethyltin dichloride
- Test material form:
- other: solution
- Details on test material:
- - Physical state: liquid
- Storage condition of test material: room temperature
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Mohican Valley Rabbitry, Loudonville, OH.
- Age at study initiation: NDA
- Weight at study initiation: Male: 2.662 - 2.893 kg. Female: 2.436 - 2.601 kg
- Housing: The animals were housed individually in suspended stainless steel cages.
- Diet (e.g. ad libitum): Purina Certified Rabbit Chow #5322 ad libitum
- Water (e.g. ad libitum): Municipal tap water treated by reverse osmosis or deionization (back-up system) ad libitum
- Acclimation period: minimum of 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°F): 66 - 72
- Humidity (%): 30 - 60 %
- Air changes (per hr): 10 - 12
- Photoperiod (hrs dark / hrs light): 12-hour light/12-hour dark cycle
IN-LIFE DATES: From: 2nd March 1993 To: 12th April 1993
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: Not specified, but covered with 4" x 8" gauze dressing.
- % coverage: ≥ 10%
- Type of wrap if used: plastic
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Residual test material was removed using gauze moistened with distilled water.
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): NDA
- Concentration (if solution): 100% - Duration of exposure:
- ca. 24 hours
- Doses:
- 200, 400 and 750 mg/kg bw
- No. of animals per sex per dose:
- 5 males, 5 females per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observations were performed daily. Bodyweights recorded on days 0, 7 and 14.
- Necropsy of survivors performed: yes
- Other examinations performed: Clinical signs, gross necropsy - Statistics:
- The LD50 and 95% confidence intervals were calculated separately for males, females and the combined sexes (when possible) using a computer adaption of the method of Litchfield and Wilcoxon. Body weight means and standard deviations were calculated separately for males and females for each LD50 level administered.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 404 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 287 - 568
- Mortality:
- 200 mg/kg: 0/5 males, 0/5 females
400 mg/kg: 4/5 males, 2/5 females
750 mg/kg: 4/5 males, 5/5 females - Clinical signs:
- other: Clinical abnormalities were observed during the LD50 study in the animals that died during the study were sacrificed moribund and in animals surviving to study termination. In the animals that died or were sacrificed moribund during the study, clinical ab
- Gross pathology:
- The most notable gross internal findings were observed in the animals that died and included reddened mucosa in the digestive tract, petechial hemorrhages, abnormally coloured fluid/mucoid contents in the digestive tract, dark red foci on the mucosa of the stomach, mottled and/or dark red thymus, mottled and/or firm, consolidated lungs, clear amber or red fluid contents in the thoracic cavity and light red foamy contents in the trachea. Cysts on the oviducts were noted in two female rabbits surviving to study termination. However, this observation was not considered significant since it is commonly observed in this strain of rabbit.
Applicant's summary and conclusion
- Interpretation of results:
- other: Acute tox. 3
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of this test, the acute dermal LD50 of [Di/Mono] Methyltin Chlorides Solution in the male rabbit was determined to be 380 mg/kg. In the female rabbit, the dermal LD50 was determined to be 413 mg/kg. In the sexes combined, the dermal LD50 was determined to be 404 mg/kg.
- Executive summary:
The single-dose dermal toxicity of (Di/Mono] Methyltin Chlorides Solution (84.8 % DMTC in mixture with MMTC) was evaluated in New Zealand White rabbits. The study was initiated with a range-finding test at levels ranging from 100 to 2000 mg/kg bw. Following the range-finding test, an LD50 study was performed in which three groups of male and female rabbits received a single dermal administration of the test material at graded dosage levels. Following dosing, the LD50 study rabbits were observed daily and weighed weekly. A gross necropsy examination was performed on all LD50 study animals at the time of death, moribund euthanasia, or scheduled euthanasia (day 14).
Mortality during the LD50 study occurred as follows:
Dose Level
(mg/kg)
Incidence of Mortality
Males
Females
Combined
200
0/5
0/5
0/10
400
4/5
2/5
6/10
750
4/5
5/5
9/10
Clinical abnormalities were observed during the LD50 study in the animals that died during the study were sacrificed moribund and in animals surviving to study termination. In the animals that died or were sacrificed moribund during the study, clinical abnormalities included slight to severe dermal irritation at the site of test article application, urine/fecal stain, soft stool/diarrhea, decreased food consumption, decreased activity, pale eyes, decreased defecation, tremors, wobbly gait, respiratory abnormalities, mucoid stools, reddened iris, prostration, partial immobility of the hindlimbs, dark material and swelling around the facial area, convulsions, dehydration, emaciation, red ocular discharge, apparent hypothermia, raised area on the abdominal region and grinding of teeth. Clinical abnormalities noted in the animals surviving to study termination included slight to severe dermal irritation at the site of test article application, decreased defecation, decreased activity, pale eyes, dark material around the facial area, partial immobility of the hindlimbs, tremors, wobbly gait, soft stool, mucoid stools, fecal stain, reddened iris, apparent decreased food consumption and raised area on the abdominal region. Weight loss was noted during the day 0-7 interval for 1 male and 1 female in the 400 mg/kg dose level and for the one surviving male in the 750 mg/kg dose level; however, these animals did gain weight during the day 7-14 interval. Body weight gain was noted for the remaining surviving animals during the test period. The most notable gross internal findings were observed in the animals that died and included reddened mucosa in the digestive tract, petechial hemorrhages, abnormally coloured fluid/mucoid contents in the digestive tract, dark red foci on the mucosa of the stomach, mottled and/or dark red thymus, mottled and/or firm, consolidated lungs, clear amber or red fluid contents in the thoracic cavity and light red foamy contents in the trachea. Cysts on the oviducts were noted in two of the female rabbits surviving to study termination. However, this observation was not considered significant since it is commonly observed in this strain of rabbit.
Under the conditions of this test, the acute dermal LD50 of [Di/Mono] Methyltin Chlorides Solution in the male rabbit was determined to be 380 mg/kg. In the female rabbit, the dermal LD50 was determined to be 413 mg/kg. In the sexes combined, the dermal LD50 was determined to be 404 mg/kg.
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