Dimethyltin dichloride

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:

direct observations: clinical cases, poisoning incidents and other

Type of information:

other: case study

Adequacy of study:

supporting study

Study period:

not reported

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Secondary source containing minimal information. Primary source not available.

Data source

Reference

Reference Type:

secondary source

Title:

Toxicological Profile for Tin and Tin Compounds

Author:

Harper, C., Llados, F., Diamond, G. & Chappell, L.L.

Year:

2005

Bibliographic source:

U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry. Primary Source: Rey C. et. al. (1984) Methyltin intoxication in six men: Toxicologic and clinical aspects. Vet Hum Toxicol 26: 121-122.

Materials and methods

Study type:

poisoning incident

Endpoint addressed:

neurotoxicity

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Case study of workers exposure.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Automatically generated during migration to IUCLID 6, no data available

IUPAC Name:

Automatically generated during migration to IUCLID 6, no data available

Test material form:

solid: crystalline

Details on test material:

Mixture of half dimethyltin and half trimethyltin chloride vapour.

Method

Type of population:

occupational

Subjects:

6 workers. Male and female.

Ethical approval:

not specified

Route of exposure:

inhalation

Exposure assessment:

not specified

Details on exposure:

Maximum exposure was a total of 1.5 hours over a 3 day working period. No estimates of exposure levels were given.

Results and discussion

Any other information on results incl. tables

Six chemical workers exposed to methyltins primarily by inhalation experienced headache, tinnitus, deafness, impaired memory, disorientation, aggressiveness, psychotic and other severe neuropsychiatric behaviour, syncope and loss of consciousness as symptoms of exposure; one subject died. The two surviving workers with the highest urinary tin levels exhibited fixed neurological effects which were not resolved more than six years after exposure. The remaining three survivors returned to work, but had memory loss, which persisted for six months.

Applicant's summary and conclusion

Conclusions:

A mixture of half dimethyltin and half trimethyltin chloride vapour.

Executive summary:

Six chemical workers exposed to methyltins primarily by inhalation experienced headache, tinnitus, deafness, impaired memory, disorientation, aggressiveness, psychotic and other severe neuropsychiatric behaviour, syncope and loss of consciousness as symptoms of exposure; one subject died. The two surviving workers with the highest urinary tin levels exhibited fixed neurological effects which were not resolved more than six years after exposure. The remaining three survivors returned to work, but had memory loss, which persisted for six months.