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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: scientifically acceptable study report

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1982
Report date:
1982

Materials and methods

Principles of method if other than guideline:
according to BASF-internal standard
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-phenoxyethyl acrylate
EC Number:
256-360-6
EC Name:
2-phenoxyethyl acrylate
Cas Number:
48145-04-6
Molecular formula:
C11H12O3
IUPAC Name:
2-phenoxyethyl prop-2-enoate
Details on test material:
Name of the test substance used in the study report: 2-Phenoxyethylacrylat
Purity: ca. 70%
Remaining acrylic acid < 1%

Test animals

Species:
mouse
Strain:
NMRI
Sex:
male/female
Details on test animals or test system and environmental conditions:
Acclimatization period: at least one week
Animal identification using cage cards (group identification).
Five animals per cage (type: stainless steel wire mesh cages).
Housing conditions: room temperature 20 - 26°C, relative humidity 45 - 75%, day/night rhythm 12 h / 12 h.
The animals were offered a standardized animal laboratory diet as well as tap water ad libitum. Food depreviation 16 hours before test substance application (water was available ad libitum).

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
olive oil
Details on exposure:
The test substance was insoluble in water.
Form of application: emulsion
Concentrations used: 4.3, 9.28 and 14% (w/v)
Application volume: 5 ml/kg
Doses:
215, 464 and 700 mg/kg
No. of animals per sex per dose:
5
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 464 - < 700 mg/kg bw
Mortality:
215 and 464 mg/kg: no deaths; 700 mg/kg: 10/10 after 14 days
Clinical signs:
Dyspnea, apathy, abnormal position, staggering, atony, paresis of the hindlimbs, missing cornea and pain reflexes, narcotic-like state, trembling, spastic gait, stretching, ruffled fur, erythema, exsiccosis, paresis, ptosis, cachexia, poor general state
Body weight:
Mean body weight male animals: 28.0 g at study start, 36.9 g after 13 days
Mean body weight female animals: 25.3 g at study start, 28.9 g after 13 days
Gross pathology:
Animals that died: multiple intra-abdominal test substance residues
Sacrificed animals: no intra-abdominal test substance residues, no adherences

Applicant's summary and conclusion

Executive summary:

464 mg/kg < LD50 by i.p. in mice < 700 mg/kg