Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: publication, which meets basic scientific principles, also published in the peer-rewieved handbook Fragrance Raw materials monographs
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
publication
Title:
Fragrance Raw materials monographs - benzylidene acetone
Author:
Opdyke, D.L.J.
Year:
1973
Bibliographic source:
Food and Cosmetics Toxicology Volume 11, Issue 6, December 1973, Page 1021

Materials and methods

Principles of method if other than guideline:
This publication lists the characteristics of benzylidene acetone, which include it to be a sensitiser in humans (Maximisation test) and a skin irritant in rabbits and humans. In addition it is stated, that the acute dermal LD50 was > 3 g/kg in the rabbit (Levenstein, 1972b).
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Benzylidene acetone (synonyms: 4-Phenyl-3-buten-2-one, benzalacetone)
- Molecular formula: C6H5-CH=CH-CO-CH3
- Substance type: organic
- Physical state: solid

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Details on dermal exposure:
no data available
Duration of exposure:
no data
Doses:
not specified, however a LD50 value of > 3 g/kg is given
No. of animals per sex per dose:
no data
Details on study design:
no data

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 3 000 mg/kg bw
Mortality:
The acute dermal LD50 was reported as > 3 g/kg in the rabbit ( Levenstein, 1972b).

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: other: EU-GHS
Conclusions:
The acute dermal LD50 was reported as > 3 g/kg in the rabbit ( Levenstein, 1972b).
Executive summary:

This publication lists the characteristics of benzylidene acetone, which include it to be a sensitiser in humans (Maximisation test) and a skin irritant in rabbits and humans (Opdyke, 1973, Fragrance raw materials monographs - benzylidene acetone). Moreover, the acute dermal LD50 was reported as > 3 g/kg in the rabbit (Levenstein, 1972b).