Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
LD50
2 030 mg/kg bw

Acute toxicity: via dermal route

Endpoint conclusion
Dose descriptor:
LD50
3 000 mg/kg bw

Additional information

Acute toxicity: oral

A publication lists the characteristics of benzylidene acetone, which include it to be a sensitiser in humans (Maximisation test) and a skin irritant in rabbits and humans (Opdyke, 1973, Fragrance raw materials monographs - benzylidene acetone). Moreover, the acute oral LD50 was reported as > 5 g/kg in the rats (Levenstein, 1972a). In addition, the acute dermal LD50 was reported as > 3 g/kg in the rabbit (Levenstein, 1972b).

Acute toxicity: inhalation

No data are available for this endpoint. However, the test substance has a low vapour pressure [0.0134 hPa est. with MPBPVPWIN v 1.43 (EPI Suite v 4.1)], so the potential for the generation of inhalable forms is low; also the use of this substance will not result in aerosols, particles or droplets of an inhalable size, so exposure to humans via the inhalatory route will be unlikely to occur, and no acute inhalation test was performed.

Acute toxicity: dermal

A publication lists the characteristics of benzylidene acetone, which include it to be a sensitiser in humans (Maximisation test) and a skin irritant in rabbits and humans (Opdyke, 1973, Fragrance raw materials monographs - benzylidene acetone). Moreover, the acute oral LD50 was reported as > 5 g/kg in the rats (Levenstein, 1972a). In addition, the acute dermal LD50 was reported as > 3 g/kg in the rabbit (Levenstein, 1972b).

Justification for classification or non-classification

The substance does not meet the criteria for classification and labelling regarding oral and dermal toxicity in accordance with European regulation (EC) No. 1272/2008.