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Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

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Description of key information

Calculation with ECOSAR v1.00 (EPIWIN software by US-EPA): EC50(96h): 63.73 mg/L / ChV(4d): 9.68 mg/L 

Key value for chemical safety assessment

EC50 for freshwater algae:
63.73 mg/L

Additional information

The acute and chronic toxicity to green algae of the test substance was predicted by the computer program ECOSAR v1.00 (EPIWIN software) by US-EPA (Chemservice GmbH, 2011). An extensive set of structure – activity relationships (SARs) is utilized by the computer program, to predict the acute and chronic toxicity for three trophic levels for aquatic species, based on the Vinyl / Allyl Ketones.The mode of toxic action for most neutral organic chemicals is narcosis, and many chemical classes present toxicity to organisms via narcosis (i.e. ethers, alcohols, ketones). However, some organic chemical classes have been identified as having a more specific mode of toxicity. These are typically organics that are reactive and ionizable and that exhibit excess toxicity in addition to narcosis (i.e. acrylates, epoxides, anilines). For green algae an EC50 of 63.73 mg/L is predicted after an test substance exposure of 96 h.

Regarding long-term toxicity, the so-called Chronic Value (ChV) is predicted, which isdefined as the geometric mean of the Lowest Observed Effect Concentration (LOEC) and the No Observed Effect Concentration (NOEC). It can just classify a substance according to a low, moderate or high toxicity concern. For the test substance a ChV(4d) of 9.68 mg/L is predicted, indicating a moderate toxicity concern.

No GLP criteria are applicable for the usage of these tools, but due to the fact that they are scientifically accepted calculation methods the estimations performed are reliable with restrictions and can be used for the chemical safety assessment.