Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 240-464-3 | CAS number: 16415-12-6
Endpoint summary
Administrative data
Description of key information
Additional information
Terrestrial toxicity studies with hexadecyl(trimethoxy)silane (CAS No. 16415-12-6) are available for soil macroorganisms (acute and chronic), terrestrial plants (chronic), and soil microorganisms (chronic).
The available acute toxicity study to earthworms (OECD 207) resulted in an LC50 (14 d) of > 1000 mg/kg soil dw whereas in the chronic toxicity study with earthworm (OECD 222) effects on biomass and reproduction were observed (NOEC = 500 mg/kg soil dw).
In the seedling emergence and seedling growth test, the toxicity to six terrestrial plant species was tested according to OECD 208 and no significant differences for shoot height, number of emerged seedlings and survival of plants were observed for all tested plant species. Oats and lettuce were the most sensitive plant species and showed a statistically reduced shoot fresh weight after 21 days. For these species the NOEC is 250 mg/kg dw.
One GLP study is available testing the effects of the test substance on nitrogen transformation in soil according to OECD 216. A significant inhibition of the microbial nitrate transformation was observed for test item concentrations ≥ 100 mg/kg soil dw. The corresponding no-observed effect concentration (NOEC) was 31.6 mg/kg soil dw which is the lowest effect value derived among terrestrial species.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
