Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 249-881-5 | CAS number: 29820-13-1
CaTG is toxic by ingestion. In contact with skin and by inhalation CaTG can cause irritating effects.
A study on the acute inhalation toxicity of CaTG on rats has been conducted in accordance with OECD Guideline No. 403. Mortality occurred in a few rats at 1022 mg/m3and above. However, any concentration-dependence or particular sex-dependence was not observed. The maximum technically achievable concentration was 2729 mg/m3. The exposure to this exposure level caused lingering and pronounced irritant effects in the upper and lower respiratory tract. Mortality is considered to be linked to acute lung edema. Due to the absence of concentration-dependent changes in particle size, the LC50is greater than the maximum technically attainable concentration. Due to technical aspects as well as animal welfare considerations, the testing of CaTG at around 3000 mg/m3is considered to meet the criteria of limit-test of contemporary testing guidelines.
The test item was applied to the skin of one group of ten Sprague-Dawley rats (five males and five females).
The application was performed with the test item in its original form at the dose-level of 2000 mg/kg. PEG 400 was used to moisten the gauze pad and ensure a good contact with the skin.
The test site was then covered by a semi-occlusive dressing for 24 hours.
Clinical signs, mortality and body weight gain were checked for a period of 14 days following the single application of the test item.
All animals were subjected to necropsy.
No clinical signs and no deaths were observed during the study.
A reduced body weight gain or a slight body weight loss was seen in 2/5 females between day 8 and day 15. The overall body weight gain of the other animals was similar to that of CIT historical control animals.
Skin reactions were noted in almost all animals between day 3 and day 14 at the latest.
No apparent abnormalities were observed at necropsy in any animal.
Thioglycolic acid and its salts are toxic by oral administration. When expressed as thioglycolate anion, the LD50values of thioglycolic acid and its salts are more or less in the same dose range.
Based on acute oral toxicity data in rats.
DSD: T, R25. Toxic if swallowed.
EU-GHS: Acute tox cat. 3. H301. Toxic if swallowed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again